product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human PDGF R alpha Antibody
catalog :
AF-307-NA
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 33
Reference
Santos A, van Unen V, Lin Z, Chirieleison S, Ha N, Batish A, et al. A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature. 2024;632:401-410 pubmed publisher
Sun Z, Chen Z, Yin M, Wu X, Guo B, Cheng X, et al. Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids. Cell Stem Cell. 2024;31:772-787.e11 pubmed publisher
Huycke T, Miyazaki H, H xe4 kkinen T, Srivastava V, Barruet E, McGinnis C, et al. Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023;: pubmed publisher
Huang Z, Lin J, Jiang H, Lin W, Huang Z, Chen J, et al. Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury. Neuropeptides. 2023;100:102348 pubmed publisher
Li W, Berlinicke C, Huang Y, Giera S, McGrath A, Fang W, et al. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells. iScience. 2023;26:106156 pubmed publisher
Aleksandrovych V, Bereza T, Ulatowska Bia x142 as M, Pasternak A, Walocha J, Pity x144 ski K, et al. Identification of PDGFRα+ cells in uterine fibroids - link between angiogenesis and uterine telocytes. Arch Med Sci. 2022;18:1329-1337 pubmed publisher
Di Pietro L, Giacalone F, Ragozzino E, Saccone V, Tiberio F, De Bardi M, et al. Non-myogenic mesenchymal cells contribute to muscle degeneration in facioscapulohumeral muscular dystrophy patients. Cell Death Dis. 2022;13:793 pubmed publisher
Wrona A, Aleksandrovych V, Bereza T, Basta P, Gil A, Ulatowska Bia x142 as M, et al. Oviductal Oxygen Homeostasis in Patients with Uterine Myoma: Correlation between Hypoxia and Telocytes. Int J Mol Sci. 2022;23: pubmed publisher
Rosa I, Ibba Manneschi L, Guasti D, Perigli G, Faussone Pellegrini M, Manetti M. Morphologic evidence of telocytes in human thyroid stromal tissue. J Cell Mol Med. 2022;26:2477-2481 pubmed publisher
Zhou X, Lu Y, Zhao F, Dong J, Ma W, Zhong S, et al. Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development. Cell Stem Cell. 2022;29:328-343.e5 pubmed publisher
Whitehead A, Hocker J, Ren B, Engler A. Improved epicardial cardiac fibroblast generation from iPSCs. J Mol Cell Cardiol. 2022;164:58-68 pubmed publisher
Yang L, Li Z, Liu G, Li X, Yang Z. Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes. Neurosci Bull. 2022;38:47-68 pubmed publisher
Farup J, Just J, de Paoli F, Lin L, Jensen J, Billeskov T, et al. Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients. Cell Metab. 2021;33:2201-2214.e11 pubmed publisher
Friedrich M, Pohin M, Jackson M, Korsunsky I, Bullers S, Rue Albrecht K, et al. IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies. Nat Med. 2021;27:1970-1981 pubmed publisher
Aleksandrovych V, Wrona A, Bereza T, Pitynski K, Gil K. Oviductal Telocytes in Patients with Uterine Myoma. Biomedicines. 2021;9: pubmed publisher
Morabito S, Miyoshi E, Michael N, Shahin S, Martini A, Head E, et al. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease. Nat Genet. 2021;53:1143-1155 pubmed publisher
Filppu P, Tanjore Ramanathan J, Granberg K, Gucciardo E, Haapasalo H, Lehti K, et al. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6: pubmed publisher
Fu Y, Yang M, Yu H, Wang Y, Wu X, Yong J, et al. Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex. Cell Rep. 2021;34:108788 pubmed publisher
Chen C, Deshmukh S, Jessa S, Hadjadj D, Lisi V, Andrade A, et al. Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell. 2020;183:1617-1633.e22 pubmed publisher
Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp C, et al. Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. Cell. 2020;182:594-608.e11 pubmed publisher
Just J, Yan Y, Farup J, Sieljacks P, Sloth M, Venø M, et al. Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. Sci Rep. 2020;10:5835 pubmed publisher
Naing Z, Hamilton S, van Zuylen W, Scott G, Rawlinson W. Differential Expression of PDGF Receptor-α in Human Placental Trophoblasts Leads to Different Entry Pathways by Human Cytomegalovirus Strains. Sci Rep. 2020;10:1082 pubmed publisher
Correa Gallegos D, Jiang D, Christ S, Ramesh P, Ye H, Wannemacher J, et al. Patch repair of deep wounds by mobilized fascia. Nature. 2019;576:287-292 pubmed publisher
Chen C, Wu S, Lin Y, Chi H, Lin S, Yeh C, et al. Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor A mediated angiogenesis in liver cancer. Theranostics. 2019;9:2361-2379 pubmed publisher
Ivey M, Kuwabara J, Riggsbee K, Tallquist M. Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival. Am J Physiol Heart Circ Physiol. 2019;317:H330-H344 pubmed publisher
Peck B, Brightwell C, Johnson D, Ireland M, Noehren B, Fry C. Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality. Am J Sports Med. 2019;47:1385-1395 pubmed publisher
Rosa I, Taverna C, Novelli L, Marini M, Ibba Manneschi L, Manetti M. Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue. Sci Rep. 2019;9:5858 pubmed publisher
Rosa I, Marini M, Guasti D, Ibba Manneschi L, Manetti M. Morphological evidence of telocytes in human synovium. Sci Rep. 2018;8:3581 pubmed publisher
Ha S, Lee M, Kurahashi M, Wei L, Jorgensen B, Park C, et al. Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia. PLoS ONE. 2017;12:e0182265 pubmed publisher
Traini C, Fausssone Pellegrini M, Guasti D, Del Popolo G, Frizzi J, Serni S, et al. Adaptive changes of telocytes in the urinary bladder of patients affected by neurogenic detrusor overactivity. J Cell Mol Med. 2018;22:195-206 pubmed publisher
Marini M, Mencucci R, Rosa I, Favuzza E, Guasti D, Ibba Manneschi L, et al. Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study. J Cell Mol Med. 2017;21:3602-3611 pubmed publisher
Daquinag A, Dadbin A, Snyder B, Wang X, Sahin A, Ueno N, et al. Non-glycanated Decorin Is a Drug Target on Human Adipose Stromal Cells. Mol Ther Oncolytics. 2017;6:1-9 pubmed publisher
Fry C, Johnson D, Ireland M, Noehren B. ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle. J Orthop Res. 2017;35:1876-1885 pubmed publisher
product information
brand :
R&D Systems
master code :
AF-307-NA
SKU :
AF-307-NA
product name :
Human PDGF R alpha Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human PDGF R alpha Antibody from R&D Systems is a goat polyclonal antibody to PDGFR alpha. This antibody reacts with human,mouse,rabbit,rat. The Human PDGF R alpha Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Immunohistochemistry,Immunodepletion,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization.
target :
PDGF R alpha
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 1-6 ug/mL
host :
Goat
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human PDGF R alpha , Gln24-Glu524, Accession # P16234
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rabbit,Rat
specificity :
Detects human PDGF R alpha in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse PDGF R alpha , recombinant human (rh) PDGF R▀, rhFGF R2, and rhFGF R3 is observed.
gene symbol :
PDGFRA
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by PDGF-AA and Neutralization by Human PDGF Ra Antibody.
accessionNumbers :
P16234
applications :
Neutralization,Immunodepletion,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
509 USD
alt names :
alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, CD140a antigen, EC 2.7.10, EC 2.7.10.1, MGC74795, PDGFR alpha, PDGFR2, PDGFRA, PDGFRA/BCR fusion, PDGF-R-alpha, platelet-derived growth factor receptor, alpha polypeptide, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein, RHEPDGFRA
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.