Human/Mouse IGF-I R/IGF1R Antibody | R&D Systems AF-305-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse IGF-I R/IGF1R Antibody

catalog :

AF-305-NA

quantity :

100 ug (also 25 ug)

price :

519 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 11

Reference
Paganoni A, Cannarella R, Oleari R, Amoruso F, Antal R, Ruzza M, et al. Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development. Int J Mol Sci. 2023;24: pubmed publisher
Ortenl xf6 f N, Vallius S, Karlsson H, Ekstr xf6 m C, Kristiansson A, Holmqvist B, et al. Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3. Fluids Barriers CNS. 2023;20:59 pubmed publisher
Pan L, Cho K, Wei X, Xu F, Lennikov A, Hu G, et al. IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy. Cell Rep. 2023;42:112889 pubmed publisher
Stueven N, Beauvais D, Hu R, Kimple R, Rapraeger A. Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTNIGF1R. Cancer Res Commun. 2023;3:97-108 pubmed publisher
Yomogita H, Ito H, Hashimoto K, Kudo A, Fukushima T, Endo T, et al. A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas. J Reprod Dev. 2023;69:32-40 pubmed publisher
Green C, Span M, Rayhanna M, Perera M, Day M. Insulin-like Growth Factor Binding Protein 3 Increases Mouse Preimplantation Embryo Cleavage Rate by Activation of IGF1R and EGFR Independent of IGF1 Signalling. Cells. 2022;11: pubmed publisher
Wang Y, Yin L, Sun X. CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway. J Exp Clin Cancer Res. 2020;39:169 pubmed publisher
Griffiths C, Bilawchuk L, McDonough J, Jamieson K, Elawar F, Cen Y, et al. IGF1R is an entry receptor for respiratory syncytial virus. Nature. 2020;583:615-619 pubmed publisher
Lamberti G, Ceccarelli C, Brighi N, Maggio I, Santini D, Mosconi C, et al. Determination of Mammalian Target of Rapamycin Hyperactivation as Prognostic Factor in Well-Differentiated Neuroendocrine Tumors. Gastroenterol Res Pract. 2017;2017:7872519 pubmed publisher
Rios Doria J, Harper J, Rothstein R, Wetzel L, Chesebrough J, MARRERO A, et al. Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies. Cancer Res. 2017;77:2686-2698 pubmed publisher
Batista Silva L, Rodrigues L, Vivarini A, Costa F, Mattos K, Costa M, et al. Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages. Sci Rep. 2016;6:27632 pubmed publisher

product information

brand :

R&D Systems

master code :

AF-305-NA

SKU :

AF-305-NA

product name :

Human/Mouse IGF-I R/IGF1R Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse IGF-I R/IGF1R Antibody from R&D Systems is a goat polyclonal antibody to IGF-I R/IGF1R. This antibody reacts with human,mouse,rat,transgenic mouse. The Human/Mouse IGF-I R/IGF1R Antibody has been validated for the following applications: Immunohistochemistry,Luciferase Reporter Assay,Western Blot,Neutralization,Functional Assay,Cell Culture,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

IGF-I R/IGF1R

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 0.5-1.5 ug/mL, Immunocytochemistry 1-15 ug/mL

host :

Goat

immunogen :

Recombinant Human IGF-I R/IGF1R extracellular domain, Accession # P08069

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects human and mouse IGF-I R/IGF1R in direct ELISAs and Western blots. In direct ELISAs and Western blots, 25-50% cross-reactivity with recombinant mouse IGF-I R is observed. In direct ELISAs, less than 1% cross-reactivity with recombinant human IGF-II R is observed.

gene symbol :

IGF1R

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IGF-I R/IGF1R antibody in MCF-7 and HDLM-2 Human Cell Lines by Immunocytochemistry (ICC).

accessionNumbers :

P08069

applications :

Immunocytochemistry,Luciferase Reporter Assay,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Functional Assay,Cell Culture

USD :

519 USD

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage