Human IGF-II/IGF2 Antibody | R&D Systems AF-292-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IGF-II/IGF2 Antibody

catalog :

AF-292-NA

quantity :

250 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 10

Reference
Scalia P, Merali C, Barrero C, Suma A, Carnevale V, Merali S, et al. Novel Isoform DTX3c Associates with UBE2N-UBA1 and Cdc48/p97 as Part of the EphB4 Degradation Complex Regulated by the Autocrine IGF-II/IRA Signal in Malignant Mesothelioma. Int J Mol Sci. 2023;24: pubmed publisher
Yi J, Kim B, Shi X, Zhan X, Lu Q, Xuan Z, et al. PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer Res. 2022;: pubmed publisher
Sandovici I, Georgopoulou A, Perez García V, Hufnagel A, Lopez Tello J, Lam B, et al. The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022;57:63-79.e8 pubmed publisher
Martín Montañez E, Valverde N, Ladrón de Guevara Miranda D, Lara E, Romero Zerbo Y, Millón C, et al. Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease. Redox Biol. 2021;46:102095 pubmed publisher
Hirsch T, Pilet J, Morcrette G, Roehrig A, Monteiro B, Molina L, et al. Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer. Cancer Discov. 2021;11:2524-2543 pubmed publisher
Hammerle C, Sandovici I, Brierley G, Smith N, Zimmer W, Zvetkova I, et al. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet. 2020;16:e1009069 pubmed publisher
De Martino M, van Koetsveld P, Feelders R, de Herder W, Dogan F, Janssen J, et al. IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer. Endocrine. 2019;64:673-684 pubmed publisher
Jalili R, Horecka J, Swartz J, Davis R, Persson H. Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies. Proc Natl Acad Sci U S A. 2018;115:E925-E933 pubmed publisher
Raimann A, Javanmardi A, Egerbacher M, Haeusler G. A journey through growth plates: tracking differences in morphology and regulation between the spine and the long bones in a pig model. Spine J. 2017;17:1674-1684 pubmed publisher
Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed publisher

product information

brand :

R&D Systems

master code :

AF-292-NA

SKU :

AF-292-NA

product name :

Human IGF-II/IGF2 Antibody

unit size :

250 ug (also 25 ug)

seo description :

The Human IGF-II/IGF2 Antibody from R&D Systems is a goat polyclonal antibody to IGF-II/IGF2. This antibody reacts with human,mouse,porcine. The Human IGF-II/IGF2 Antibody has been validated for the following applications: Neutralization,Affinity Assay,ELISA Microarray Development,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

IGF-II/IGF2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 0.2-0.8 ug/mL

host :

Goat

immunogen :

E. coli -derived recombinant human IGF-II/IGF2, Ala25-Glu91, Accession # P01344

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Porcine

specificity :

Detects human IGF-II/IGF2 in direct ELISAs and Western blots. In direct ELISAs, approximately 60% cross-reactivity with recombinant mouse IGF-II/IGF2 is observed and less than 1% cross-reactivity with recombinant human IGF-I/IGF1 is observed.

gene symbol :

IGF2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by IGF-II/IGF2 and Neutralization by Human IGF-II/IGF2 Antibody.

accessionNumbers :

P01344

applications :

Affinity Assay,ELISA Microarray Development,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

509 USD

alt names :

C11orf43, chromosome 11 open reading frame 43, FLJ22066, FLJ44734, GRDF, IGF2, IGF-2, IGFII, IGF-II, insulin-like growth factor 2 (somatomedin A), insulin-like growth factor II, insulin-like growth factor type 2, MSA, PEG2, PP9974, somatomedin-A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage