Human HB-EGF Antibody | R&D Systems AF-259-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human HB-EGF Antibody

catalog :

AF-259-NA

quantity :

250 ug (also 25 ug)

price :

529 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 27

Reference
Won K, Lee R, Choi S, Kim J, Hwang S, Nah S. Gintonin-Induced Wound-Healing-Related Responses Involve Epidermal-Growth-Factor-like Effects in Keratinocytes. Int J Mol Sci. 2023;24: pubmed publisher
Okamoto M, Sasai M, Kuratani A, Okuzaki D, Arai M, Wing J, et al. A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity. Cell Rep. 2023;42:112813 pubmed publisher
Godoy R, Cober N, Cook D, McCourt E, Deng Y, Wang L, et al. Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation. elife. 2023;12: pubmed publisher
Yu Q, Gamayun I, Wartenberg P, Zhang Q, Qiao S, Kusumakshi S, et al. Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis. Nat Commun. 2023;14:1588 pubmed publisher
Casanova N, Reyes Hernon V, Gregory T, Sun B, Bermudez T, Hufford M, et al. Biochemical and genomic identification of novel biomarkers in progressive sarcoidosis: HBEGF, eNAMPT, and ANG-2. Front Med (Lausanne). 2022;9:1012827 pubmed publisher
Zhang C, Vincelette L, Reimann F, Liberles S. A brainstem circuit for nausea suppression. Cell Rep. 2022;39:110953 pubmed publisher
Wang H, He L, Li Y, Pu W, Zhang S, Han X, et al. Dual Cre and Dre recombinases mediate synchronized lineage tracing and cell subset ablation in vivo. J Biol Chem. 2022;298:101965 pubmed publisher
Schreier B, Dubourg V, H xfc bschmann S, Rabe S, Mildenberger S, Gekle M. Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation. Cell Mol Life Sci. 2021;79:57 pubmed publisher
Watanabe J, Takayanagi Y, Yoshida M, Hattori T, Saito M, Kohno K, et al. Conditional ablation of vasopressin-synthesizing neurons in transgenic rats. J Neuroendocrinol. 2021;33:e13057 pubmed publisher
Fujita M, Sasada M, Eguchi M, Iyoda T, Okuyama S, Osawa T, et al. Induction of cellular senescence in fibroblasts through β1-integrin activation by tenascin-C-derived peptide and its protumor effect. Am J Cancer Res. 2021;11:4364-4379 pubmed
Stubbs C, Biancucci M, Vidimar V, Satchell K. RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines. Sci Rep. 2021;11:17925 pubmed publisher
Hoeffel G, Debroas G, Roger A, Rossignol R, Gouilly J, Laprie C, et al. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Nature. 2021;594:94-99 pubmed publisher
Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, et al. Structural basis of malaria RIFIN binding by LILRB1-containing antibodies. Nature. 2021;592:639-643 pubmed publisher
Morgan E, Scarth J, Patterson M, Wasson C, Hemingway G, Barba Moreno D, et al. E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer. Cell Death Differ. 2021;28:1669-1687 pubmed publisher
Zhang C, Kaye J, Cai Z, Wang Y, Prescott S, Liberles S. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021;109:461-472.e5 pubmed publisher
Lee S, Commisso C. Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras. Biochem Biophys Res Commun. 2020;533:424-428 pubmed publisher
Hastings R, Mikesh M, Lee Y, Thompson W. Morphological remodeling during recovery of the neuromuscular junction from terminal Schwann cell ablation in adult mice. Sci Rep. 2020;10:11132 pubmed publisher
Fu E, Liu T, Yu S, Chen X, Song L, Lou H, et al. M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB‑EGF. Oncol Rep. 2020;44:698-710 pubmed publisher
Prescott S, Umans B, Williams E, Brust R, Liberles S. An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents. Cell. 2020;181:574-589.e14 pubmed publisher
Rao L, Giannico D, Leone P, Solimando A, Maiorano E, Caporusso C, et al. HB-EGF-EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma. Cancers (Basel). 2020;12: pubmed publisher
Pu xf1 al V, Paisley C, Brecha F, Lee M, Perelli R, Wang J, et al. Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia. PLoS Biol. 2019;17:e3000492 pubmed publisher
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Branco D, da Costa N, Abe C, Kataoka M, Pinheiro J, Alves Júnior S. HIF-1α, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:e8-e17 pubmed publisher
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product information

brand :

R&D Systems

master code :

AF-259-NA

SKU :

AF-259-NA

product name :

Human HB-EGF Antibody

unit size :

250 ug (also 25 ug)

seo description :

The Human HB-EGF Antibody from R&D Systems is a goat polyclonal antibody to HB-EGF. This antibody reacts with human,mouse,primate - chlorocebus pygerythrus (vervet monkey),rat,transgenic mouse. The Human HB-EGF Antibody has been validated for the following applications: Immunohistochemistry,Flow Cytometry,Western Blot,Neutralization,Cell Culture,ELISA Capture,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).

target :

HB-EGF

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 0.1-0.6 ug/mL, ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL

host :

Goat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HB-EGF (R D Systems, Catalog # 259-HE), Asp63-Leu148, Accession # Q99075

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Primate - Chlorocebus pygerythrus (Vervet Monkey),Rat,Transgenic Mouse

specificity :

Detects human HB-EGF in ELISAs and Western blots. In direct ELISAs, less than 1% cross reactivity with recombinant mouse HB-EGF is observed. In sandwich immunoassays, less than 0.1% cross-reactivity with recombinant human (rh) Amphiregulin, rhBetacellulin, rhEpiregulin, and recombinant mouse Epigen is observed.

gene symbol :

HBEGF

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by HB-EGF and Neutralization by Human HB-EGF Antibody.

accessionNumbers :

Q99075

applications :

ELISA Capture (Matched Antibody Pair),Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,Cell Culture,ELISA Capture

USD :

529 USD

alt names :

diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor), Dtr, DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor), Dts, DTSF, HBEGF, Hegfl, heparin-binding EGF-like growth factor, heparin-binding epidermal growth factor, proheparin-binding EGF-like growth factor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage