product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Pleiotrophin/PTN Antibody
catalog :
AF-252-PB
quantity :
250 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 7
Reference
Sun Z, Chen Z, Yin M, Wu X, Guo B, Cheng X, et al. Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids. Cell Stem Cell. 2024;31:772-787.e11 pubmed publisher
Rajachandran S, Zhang X, Cao Q, Caldeira Brant A, Zhang X, Song Y, et al. Dissecting the spermatogonial stem cell niche using spatial transcriptomics. Cell Rep. 2023;42:112737 pubmed publisher
Ganguly D, Schmidt M, Coleman M, Ngo T, Sorrelle N, Dominguez A, et al. Pleiotrophin drives a prometastatic immune niche in breast cancer. J Exp Med. 2023;220: pubmed publisher
Zheng Z, He H, Tang X, Zhang H, Gou F, Yang H, et al. Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis. Cell Stem Cell. 2022;29:1562-1579.e7 pubmed publisher
Himburg H, Roos M, Fang T, Zhang Y, Termini C, Schlussel L, et al. Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. J Clin Invest. 2020;130:315-328 pubmed publisher
Nikolakopoulou A, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen M, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019;22:1089-1098 pubmed publisher
Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, et al. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal. 2016;9:ra103 pubmed
product information
master code :
AF-252-PB
SKU :
AF-252-PB
product name :
Human Pleiotrophin/PTN Antibody
unit size :
250 ug (also 25 ug)
description :
The Human Pleiotrophin/PTN Antibody from R&D Systems is a goat polyclonal antibody to Pleiotrophin/PTN. This antibody reacts with human,mouse,rabbit,rat. The Human Pleiotrophin/PTN Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Bioassay,ELISA Development (Capture),Neutralization,Functional Assay,Cell Culture,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
Pleiotrophin/PTN
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Pleiotrophin/PTN, Gly33-Asp168, Accession # P21246
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rabbit,Rat
specificity :
Detects human Pleiotrophin/PTN in direct ELISAs and Western blots. In direct ELISAs, less than 50% cross-reactivity with recombinant mouse PTN is observed, and less than 1% cross-reactivity with recombinant human Midkine is observed.
gene symbol :
PTN
top caption :
Pleiotrophin/PTN antibody in Human Pituitary by Immunohistochemistry (IHC-P).
accessionNumbers :
P21246
applications :
Immunohistochemistry,Western Blot,Bioassay,ELISA Development (Capture),Neutralization,Functional Assay,Cell Culture,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
499 USD
alt names :
HARP, HBBM, HB-GAM, HBGF8, HBNF, HBNF1, HBNF-1, Heparin-binding brain mitogen, HNGF-8, NEGF1HBGF-8, neurite growth-promoting factor 1, neurite growth-promoting factor1), OSF-1, Osteoblast-specific factor 1, pleiotrophin, PTN
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.