Human TGF┐▀ RII Antibody | R&D Systems AF-241-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TGF┐▀ RII Antibody

catalog :

AF-241-NA

quantity :

250 ug (also 25 ug)

price :

539 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

more info or order :

R&D Systems product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; loading ...; fig 4d	Zhang M, Pan X, Fujiwara K, Jurcak N, Muth S, Zhou J, et al. Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism. Signal Transduct Target Ther. 2021;6:366 pubmed publisher
immunohistochemistry; mouse; 1:100; loading ...; fig 1a	Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. elife. 2019;8: pubmed publisher
	Windus L, Matigian N, Avery V. Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases. Biology (Basel). 2023;12: pubmed publisher
	Bosseboeuf E, Chikh A, Chaker A, Mitchell T, Vignaraja D, Rajendrakumar R, et al. Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. Sci Signal. 2023;16:eabo4863 pubmed publisher
	Kl xfc ck V, Cab x103 u G, Mies L, Bukkems F, van Emst L, Bakker R, et al. TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells. Arthritis Res Ther. 2023;25:30 pubmed publisher
	Trzeciak E, Zimmer N, K xe4 mmerer P, Thiem D, Al Nawas B, Tuettenberg A, et al. GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate. Biomedicines. 2022;10: pubmed publisher
	Gringhuis S, Kaptein T, Remmerswaal E, Drewniak A, Wevers B, Theelen B, et al. Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs. Nat Immunol. 2022;23:1735-1748 pubmed publisher
	Zhou X, Li X, Wang R, Hua D, Sun C, Yu L, et al. Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis. Cell Death Dis. 2022;13:818 pubmed publisher
	Hanson I, Pitman K, Altanerova U, Altaner x, Malinen E, Edin N. Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding. Int J Mol Sci. 2022;23: pubmed publisher
	Ju N, Hayashi H, Shimamura M, Baba S, Yoshida S, Morishita R, et al. Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice. Sci Rep. 2022;12:12474 pubmed publisher
	Zimmer N, Krebs F, Zimmer S, Mitzel Rink H, Kumm E, Jurk K, et al. Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis. Cancers (Basel). 2020;12: pubmed publisher
	Lin L, Kost E, Lin C, Valente P, Wang C, Kolonin M, et al. PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer. Cell Rep. 2020;33:108253 pubmed publisher
	Devocelle A, Lecru L, Francois H, Desterke C, Gallerne C, Eid P, et al. Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis. Int J Cell Biol. 2019;2019:9151394 pubmed publisher
	Thepmalee C, Panya A, Junking M, Chieochansin T, Yenchitsomanus P. Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells. Hum Vaccin Immunother. 2018;14:1423-1431 pubmed publisher
	Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
	Boyan B, Hyzy S, Pan Q, Scott K, Coutts R, Healey R, et al. 24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats. PLoS ONE. 2016;11:e0161782 pubmed publisher
	Wu S, Majeed S, Evans T, Camus M, Wong N, Schollmeier Y, et al. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016;113:9816-21 pubmed publisher
	Chaudhry S, Cain S, Morgan A, Dallas S, Shuttleworth C, Kielty C. Fibrillin-1 regulates the bioavailability of TGFbeta1. J Cell Biol. 2007;176:355-67 pubmed

product information

master code :

AF-241-NA

SKU :

AF-241-NA

product name :

Human TGF┐▀ RII Antibody

unit size :

250 ug (also 25 ug)

description :

The Human TGF¿ß RII Antibody from R&D Systems is a goat polyclonal antibody to TGF-beta RII. This antibody reacts with feline,human,mouse,rabbit,rat. The Human TGF¿ß RII Antibody has been validated for the following applications: Western Blot,Neutralization,Bioassay,Blocking,CyTof,Functional Assay,Cell Culture,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Flow Cytometry,ELISA Capture (Matched Antibody Pair),CyTOF-ready.

target :

TGF-beta RII

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TGF┐▀ RII, Ile24-Asp159, Accession # P37173.2

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Feline,Human,Mouse,Rabbit,Rat

specificity :

Detects human TGF┐▀ RII in direct ELISAs and Western blots.

gene symbol :

TGFBR2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human TGF-ss RII antibody by Western Blot.

accessionNumbers :

P37173.2

applications :

Neutralization,Bioassay,Blocking,CyTof,Western Blot,Functional Assay,Cell Culture,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Flow Cytometry,ELISA Capture (Matched Antibody Pair),CyTOF-ready

USD :

539 USD

alt names :

AAT3, EC 2.7.11, EC 2.7.11.30, FAA3, HNPCC6, LDS1B, LDS2B, MFS2, RIIC, TAAD2, tbetaR-II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGF-beta receptor type-2, TGF-beta type II receptor, TGFbetaRII, TGFbeta-RII, TGFBR2, TGF-bRII, TGFR-2, transforming growth factor beta receptor type IIC, transforming growth factor, beta receptor II (70/80kDa), transforming growth factor, beta receptor II (70/80kDa) isoform 1, transforming growth factor, beta receptor II (70/80kDa) isoform 2, transforming growth factor, beta receptor II (70-80kD), Transforming growth factor-beta receptor type II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage