Human gp130 Antibody | R&D Systems AF-228-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human gp130 Antibody

catalog :

AF-228-NA

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, proximity ligation assay

more info or order :

R&D Systems product webpage

citations: 3

Reference
Chandrasekar B, Mummidi S, Demarco V, Higashi Y. Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration. Mediators Inflamm. 2023;2023:6112301 pubmed publisher
M xfc ller S, Shmueli M, Feng X, T xfc shaus J, Schumacher N, Clark R, et al. The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Mol Neurodegener. 2023;18:13 pubmed publisher
Filppu P, Tanjore Ramanathan J, Granberg K, Gucciardo E, Haapasalo H, Lehti K, et al. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6: pubmed publisher

product information

master code :

AF-228-NA

SKU :

AF-228-NA

product name :

Human gp130 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human gp130 Antibody from R&D Systems is a goat polyclonal antibody to gp130/CD130. This antibody reacts with human,primate. The Human gp130 Antibody has been validated for the following applications: Co-Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Proximity Ligation Assay,Immunocytochemistry.

target :

gp130

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human gp130, Leu24-Glu619 (Glu619Asp), Accession # P40189

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Primate

specificity :

Detects human gp130 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant rat gp130, recombinant mouse gp130, recombinant human (rh) IL-1 sRI, rhIL-1 sRII, rhIL-2 sR▀, rhIL-2 sR gamma , rhIL-4 sR, and rhIL-6 sR is observed.

gene symbol :

IL6ST

endotoxin note :

<0.70 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by Oncostatin M/OSM and Neutralization by Human gp130 Antibody.

accessionNumbers :

P40189

applications :

Co-Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Proximity Ligation Assay,Immunocytochemistry

USD :

499 USD

alt names :

CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage