product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-10 Antibody
catalog :
AF-217-NA
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, rhesus macaque
application :
western blot, immunohistochemistry, neutralization, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 8
Reference
van Eijs M, Ter Linde J, Baars M, Amini M, Lacl xe9 M, Brand E, et al. Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor colitis. iScience. 2023;26:107891 pubmed publisher
Dumigan A, Cappa O, Morris B, S xe1 Pessoa J, Calderón Gonzalez R, Mills G, et al. In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection. EMBO Mol Med. 2022;14:e16888 pubmed publisher
Shrestha P, Davis D, Jaeger H, Stream A, Aisabor A, Yarchoan R. Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2. PLoS Pathog. 2021;17:e1009091 pubmed publisher
Fay N, Muthusamy B, Nyugen L, Desai R, Taverner A, MacKay J, et al. A Novel Fusion of IL-10 Engineered to Traffic across Intestinal Epithelium to Treat Colitis. J Immunol. 2020;205:3191-3204 pubmed publisher
Zheng X, Fernando V, Sharma V, Walia Y, Letson J, Furuta S. Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem Pharmacol. 2020;176:113887 pubmed publisher
Kishimoto W, Nishikori M, Arima H, Miyoshi H, Sasaki Y, Kitawaki T, et al. Expression of Tim-1 in primary CNS lymphoma. Cancer Med. 2016;5:3235-3245 pubmed publisher
Xu J, Han R, Kim D, Mo J, Jin Y, Rha K, et al. Role of Interleukin-10 on Nasal Polypogenesis in Patients with Chronic Rhinosinusitis with Nasal Polyps. PLoS ONE. 2016;11:e0161013 pubmed publisher
Saulep Easton D, Vincent F, Quah P, Wei A, Ting S, Croce C, et al. The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia. 2016;30:163-72 pubmed publisher
product information
brand :
R&D Systems
master code :
AF-217-NA
SKU :
AF-217-NA
product name :
Human IL-10 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human IL-10 Antibody from R&D Systems is a goat polyclonal antibody to IL-10. This antibody reacts with human,n/a,primate - macaca mulatta (rhesus macaque). The Human IL-10 Antibody has been validated for the following applications: Neutralization,Assay Development,Western Blot,Functional Assay,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western.
target :
IL-10
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 10 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 0.2-1.0 ug/mL
host :
Goat
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-10, Ser19-Asn178, Accession # P22301
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,N/A,Primate - Macaca mulatta (Rhesus Macaque)
specificity :
Detects human IL-10 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant Epstein-Barr virus IL-10 is observed and less than 20% cross-reactivity with recombinant mouse IL-10, recombinant feline IL-10, recombinant porcine IL-10, recombinant equine IL-10, and recombinant rat IL-10 is observed.
gene symbol :
IL10
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Human IL-10 antibody by Western Blot.
accessionNumbers :
P22301
applications :
Simple Western,Assay Development,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Functional Assay
USD :
499 USD
alt names :
CSIF, CSIFMGC126450, Cytokine synthesis inhibitory factor, GVHDS, IL10, IL10A, IL-10MGC126451, interleukin 10, interleukin-10, TGIF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.