product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-1▀/IL-1F2 Antibody
catalog :
AF-201-NA
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, dogs, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, dot blot
more info or order :
citations: 54
Reference
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Díaz Maroto N, Garcia Vicién G, Polcaro G, Bañuls M, Albert N, Villanueva A, et al. The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation. Int J Mol Sci. 2021;22: pubmed publisher
Zhou B, Abbott D. Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases. Cell Rep. 2021;35:108998 pubmed publisher
Read S, Gloss B, Liddle C, George J, Ahlenstiel G. Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis. J Inflamm Res. 2021;14:1257-1270 pubmed publisher
Gowda P, Patrick S, Joshi S, Kumawat R, Sen E. Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication. Cytokine. 2021;142:155496 pubmed publisher
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Gong Q, Robinson K, Xu C, Huynh P, Chong K, Tan E, et al. Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. Nat Commun. 2021;12:188 pubmed publisher
Gritsenko A, Yu S, Martín Sánchez F, Díaz Del Olmo I, Nichols E, Davis D, et al. Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro. Front Immunol. 2020;11:565924 pubmed publisher
Mitchell P, Roncaioli J, Turcotte E, Goers L, Chavez R, Lee A, et al. NAIP-NLRC4-deficient mice are susceptible to shigellosis. elife. 2020;9: pubmed publisher
Guo H, Ting J. Inflammasome Assays In Vitro and in Mouse Models. Curr Protoc Immunol. 2020;131:e107 pubmed publisher
Zhai Z, Samson J, Yamauchi T, Vaddi P, Matsumoto Y, Dinarello C, et al. Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma. Cancers (Basel). 2020;12: pubmed publisher
Nogie x107 A, Bzowska M, Demczuk A, Varol C, Guzik K. Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs. Front Immunol. 2020;11:1592 pubmed publisher
Linder A, Bauernfried S, Cheng Y, Albanese M, Jung C, Keppler O, et al. CARD8 inflammasome activation triggers pyroptosis in human T cells. EMBO J. 2020;39:e105071 pubmed publisher
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Chen Y, Yang Z, Deng B, Wu D, Quan Y, Min Z. Interleukin 1β/1RA axis in colorectal cancer regulates tumor invasion, proliferation and apoptosis via autophagy. Oncol Rep. 2020;43:908-918 pubmed publisher
Wang Z, Zhou H, Zheng H, Zhou X, Shen G, Teng X, et al. Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation. Autophagy. 2021;17:529-552 pubmed publisher
Cheng R, Billet S, Liu C, Haldar S, Choudhury D, Tripathi M, et al. Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Oncogene. 2020;39:1543-1556 pubmed publisher
Kim J, Kim W, Ha K, Han E, Park W, Yang S, et al. Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages. Int J Stem Cells. 2019;12:419-429 pubmed publisher
Faraj T, Stover C, Erridge C. Dietary Toll-Like Receptor Stimulants Promote Hepatic Inflammation and Impair Reverse Cholesterol Transport in Mice via Macrophage-Dependent Interleukin-1 Production. Front Immunol. 2019;10:1404 pubmed publisher
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, et al. PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 2019;26:101254 pubmed publisher
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Hendrawan K, Whittington C, Brandley M, Belov K, Thompson M. The Regulation of Uterine Proinflammatory Gene Expression during Pregnancy in the Live-Bearing Lizard, Pseudemoia entrecasteauxii. J Exp Zool B Mol Dev Evol. 2017;328:334-346 pubmed publisher
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Primiano M, Lefker B, Bowman M, Bree A, Hubeau C, Bonin P, et al. Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation. J Immunol. 2016;197:2421-33 pubmed publisher
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product information
brand :
R&D Systems
master code :
AF-201-NA
SKU :
AF-201-NA
product name :
Human IL-1▀/IL-1F2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human IL-1ß/IL-1F2 Antibody from R&D Systems is a goat polyclonal antibody to IL-1 beta/IL-1F2. This antibody reacts with amphibian,canine,human,lizard,mouse,primate - macaca mulatta (rhesus macaque). The Human IL-1ß/IL-1F2 Antibody has been validated for the following applications: Immunocytochemistry,Western Blot,Bioassay,Immunohistochemistry,Cell Culture,Blocking/Neutralizing,Dot Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Simple Western,Dual RNAscope ISH-IHC Compatible.
target :
IL-1 beta/IL-1F2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Simple Western 1 ug/mL, Immunohistochemistry 1-15 ug/mL, Neutralization, Immunocytochemistry 5-15 ug/mL, Dual RNAscope ISH-IHC 1-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant human IL-1▀/IL-1F2, Ala117-Ser269, Accession # NP_000567
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Amphibian,Canine,Human,Lizard,Mouse,Primate - Macaca mulatta (Rhesus Macaque)
specificity :
Detects human IL-1▀/IL-1F2 in direct ELISAs and Western blots.
gene symbol :
IL1B
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
Antibody validation :
Orthogonal Validation
top caption :
IL-1ss/IL-1F2 antibody in Human Tonsil Using Dual RNAscope«ISH and IHC.
accessionNumbers :
NP_000567
applications :
Simple Western,Dual RNAscope ISH-IHC Compatible,Bioassay,Blocking/Neutralizing,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Dot Blot,Neutralization,Immunocytochemistry,Functional Assay,Cell Culture
USD :
509 USD
alt names :
catabolin, IL-1, IL1 beta, IL-1 beta, IL-1b, IL1B, IL1-BETA, IL-1F2, IL1F2IL-1 beta, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.