Recombinant Human ICAM-1/CD54 Protein, CF | R&D Systems ADP4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ICAM-1/CD54 Protein, CF

catalog :

ADP4

quantity :

50 ug (also 200 ug)

price :

339 USD

citations: 26

Reference
Gamara J, Davis L, Rollet Labelle E, Hongu T, Funakoshi Y, Kanaho Y, et al. Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration. Mediators Inflamm. 2020;2020:2713074 pubmed publisher
Caccuri F, Bugatti A, Corbellini S, Roversi S, Zani A, Mazzuca P, et al. The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). Int J Mol Sci. 2019;20: pubmed publisher
Ayala Nuñez N, Follain G, Delalande F, Hirschler A, Partiot E, Hale G, et al. Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells. Nat Commun. 2019;10:4430 pubmed publisher
Bertrand M, Abran M, Maafi F, Busseuil D, Merlet N, Mihalache Avram T, et al. In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes. Sci Rep. 2019;9:2670 pubmed publisher
Wolf D, Anto Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann J, et al. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nat Commun. 2018;9:525 pubmed publisher
Gil Krzewska A, Saeed M, Oszmiana A, Fischer E, Lagrue K, Gahl W, et al. An actin cytoskeletal barrier inhibits lytic granule release from natural killer cells in patients with Chediak-Higashi syndrome. J Allergy Clin Immunol. 2018;142:914-927.e6 pubmed publisher
Maus R, Jakub J, Nevala W, Christensen T, Noble Orcutt K, Sachs Z, et al. Human Melanoma-Derived Extracellular Vesicles Regulate Dendritic Cell Maturation. Front Immunol. 2017;8:358 pubmed publisher
Mikuła Pietrasik J, Uruski P, Kucińska M, Tykarski A, Ksiazek K. The protective activity of mesothelial cells against peritoneal growth of gastrointestinal tumors: The role of soluble ICAM-1. Int J Biochem Cell Biol. 2017;86:26-31 pubmed publisher
MikuÅ‚a Pietrasik J, Uruski P, SosiÅ„ska P, Maksin K, Piotrowska Kempisty H, KuciÅ„ska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
Henry K, Sulea T, van Faassen H, Hussack G, Purisima E, Mackenzie C, et al. A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies. PLoS ONE. 2016;11:e0163113 pubmed publisher
Jensen M, Bajic G, Zhang X, Laustsen A, Koldsø H, Skeby K, et al. Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3. J Biol Chem. 2016;291:16963-76 pubmed publisher
Lagrue K, Carisey A, Morgan D, Chopra R, Davis D. Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds. Blood. 2015;126:50-60 pubmed publisher
Borgman K, van Zanten T, Manzo C, Cabezón R, Cambi A, Benitez Ribas D, et al. Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells. PLoS ONE. 2014;9:e99589 pubmed publisher
Doritchamou J, Sossou tchatcha S, Cottrell G, Moussiliou A, Hounton Houngbeme C, Massougbodji A, et al. Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy. PLoS ONE. 2014;9:e98577 pubmed publisher
Weckbach L, Gola A, Winkelmann M, Jakob S, Groesser L, Borgolte J, et al. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ?2 integrins (CD11/CD18). Blood. 2014;123:1887-96 pubmed publisher
Dalli J, Norling L, Montero Melendez T, Federici Canova D, Lashin H, Pavlov A, et al. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med. 2014;6:27-42 pubmed publisher
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Li N, Mao D, Lü S, Tong C, Zhang Y, Long M. Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation. J Immunol. 2013;190:4371-81 pubmed publisher
Brown A, Dobbie I, Alakoskela J, Davis I, Davis D. Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins. Blood. 2012;120:3729-40 pubmed publisher
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product information

brand :

R&D Systems

master code :

ADP4

SKU :

ADP4-050

product name :

Recombinant Human ICAM-1/CD54 Protein, CF

description :

The Recombinant Human ICAM-1/CD54 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ICAM-1/CD54 Protein, CF has been validated for the following applications: Bioactivity.

target :

ICAM-1/CD54

category :

Proteins and Enzymes

unit size :

50 ug (also 200 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS, containing Calcium and Magnesium with Sorbitol and with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

70-90 kDa, reducing conditions

theoretical molecular weight :

50 kDa

gene symbol :

ICAM1

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 5 x 104 cells/well are added to Recombinant Human ICAM-1/CD54 coated plates (12.5 µg/mL with 100 µL/well), 30% cells will adhere after 1 hour incubation at 37 °C. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

ADP4

accessionNumbers :

CAA30051

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human ICAM-1/CD54 protein Met1-Glu480

2020 USD :

339

2021 USD :

339 USD

alt names :

BB2, CD54, CD54 antigen, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, Major group rhinovirus receptor, P3.58

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.