product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse IL-1▀/IL-1F2 Antibody
catalog :
AB-401-NA
quantity :
1 mg
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, neutralization
more info or order :
R&D Systems product webpage
citations: 16
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5e
Sharma A, Choi J, Stefanovic N, Al Sharea A, Simpson D, Mukhamedova N, et al. Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis. Diabetes. 2021;70:772-787 pubmed publisher
Li Y, Zhuang Y, Chen Y, Wang G, Tang Z, Zhong Y, et al. Euphorbia factor L2 alleviated gouty inflammation by specifically suppressing both the priming and activation of NLRP3 inflammasome. Int Immunopharmacol. 2024;138:112598 pubmed publisher
Chen M, Yu S, Gao Y, Li J, Wang X, Wei B, et al. TRAF6-TAK1-IKKβ pathway mediates TLR2 agonists activating "one-step" NLRP3 inflammasome in human monocytes. Cytokine. 2023;169:156302 pubmed publisher
Feng J, Meng W, Chen L, Zhang X, Markazi A, Yuan W, et al. N6-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections. MBio. 2023;14:e0334922 pubmed publisher
Lin W, Li L, Hsiao Y, Wong W, Chiu H, Hsu H, et al. Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity. Front Immunol. 2022;13:870627 pubmed publisher
Arumugam S, Qin Y, Liang Z, Han S, Boodapati S, Li J, et al. GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation. Cell Death Differ. 2022;: pubmed publisher
Ding X, Kambara H, Guo R, Kanneganti A, Acosta Zaldívar M, Li J, et al. Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages. Nat Commun. 2021;12:6699 pubmed publisher
Childers G, Perry C, Blachut B, Martin N, Bortner C, Sieber S, et al. Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds. Environ Health Perspect. 2021;129:47015 pubmed publisher
Wu C, Gan C, Li L, Chang J, Chen S, Menon M, et al. A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction. Front Immunol. 2020;11:607564 pubmed publisher
Sato K, Tobo A, Mogi C, Tobo M, Yamane N, Tosaka M, et al. The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model. Sci Rep. 2020;10:17193 pubmed publisher
Saleh H, Nassar A, Noreldin A, Samak D, Elshony N, Wasef L, et al. Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats. Molecules. 2020;25: pubmed publisher
Li L, Chen T, Chiu H, Hsu C, Wang C, Tai T, et al. Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production in Shigella sonnei-Infected Macrophages. Front Immunol. 2020;11:1115 pubmed publisher
Jeong Y, Walsh M, Yu J, Shen H, Wherry E, Choi Y. Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes. J Immunol. 2020;205:760-766 pubmed publisher
Chiu H, Li L, Hsieh C, Rao Y, Chen F, Chen A, et al. Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome. Sci Rep. 2019;9:5603 pubmed publisher
Nakazawa H, Ikeda K, Shinozaki S, Yasuhara S, Yu Y, Martyn J, et al. Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle. FEBS Open Bio. 2019;9:348-363 pubmed publisher
Chen J, Chen Z. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018;564:71-76 pubmed publisher
product information
brand :
R&D Systems
master code :
AB-401-NA
SKU :
AB-401-NA
product name :
Mouse IL-1▀/IL-1F2 Antibody
unit size :
1 mg
seo description :
The Mouse IL-1ß/IL-1F2 Antibody from R&D Systems is a goat polyclonal antibody to IL-1 beta/IL-1F2. This antibody reacts with mouse,rat. The Mouse IL-1ß/IL-1F2 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Neutralization,Simple Western.
target :
IL-1 beta/IL-1F2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 50 ug/mL, Neutralization 2-12 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant mouse IL-1▀/IL-1F2, Val118-Ser269, Accession # P10749
isotype :
IgG
purity :
Protein A or G purified
species :
Mouse
specificity :
Detects mouse IL-1▀/IL-1F2 in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant cotton rat IL-1▀ and recombinant rhesus monkey IL-1▀ is observed, approximately 15% cross-reactivity with recombinant rat IL-1▀ and recombinant rabbit IL-1▀ is observed, and less than 10% cross-reactivity with recombinant canine IL-1▀, recombinant equine IL-1▀, recombinant guinea pig IL-1▀, recombinant porcine IL-1▀, recombinant feline IL-1▀, and recombinant human IL-1▀ is observed.
gene symbol :
IL1B
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by IL-1ss/IL-1F2 and Neutral-ization by Mouse IL-1ss/IL-1F2 Antibody.
accessionNumbers :
P10749
applications :
Simple Western,Western Blot,Neutralization
USD :
509 USD
alt names :
catabolin, IL-1, IL1 beta, IL-1 beta, IL-1b, IL1B, IL1-BETA, IL-1F2, IL1F2IL-1 beta, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.