Recombinant Cynomolgus LAG-3 His-tag Protein, CF | R&D Systems 9992-L3-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Cynomolgus LAG-3 His-tag Protein, CF

catalog :

9992-L3-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 1

Reference
Edwards C, Sette A, Cox C, Di Fiore B, Wyre C, Sydoruk D, et al. The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity. Br J Cancer. 2021;: pubmed publisher

product information

master code :

9992-L3

SKU :

9992-L3-050

product name :

Recombinant Cynomolgus LAG-3 His-tag Protein, CF

unit size :

50 ug

description :

The Recombinant Cynomolgus LAG-3 His-tag Protein, CF from R&D Systems is derived from CHO. The Recombinant Cynomolgus LAG-3 His-tag Protein, CF has been validated for the following applications: Bioactivity.

target :

LAG-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Cynomolgus Monkey

observed molecular weight :

47-61 kDa, reducing conditions

theoretical molecular weight :

47 kDa

details of functionality :

Measured by its ability to induce TNF-alpha secretion by JAWSII mouse immature dendritic cells. The ED50 for this effect is 0.15-0.9 ╡g/mL in the presence of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050R ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Cynomolgus LAG-3 His-tag Protein Bioactivity

accessionNumbers :

XP_005570011.1

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived cynomolgus monkey LAG-3 protein Val20-Leu450 (Pro 74), with a C-terminal 6-His tag

source short :

CHO

USD :

432 USD

alt names :

CD223, CD223 antigen, LAG3, LAG-3, lymphocyte activating 3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, Secreted lymphocyte activation gene 3 protein, sLAG-3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, <= -20 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, <= -20 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage