This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-21R Fc Chimera Protein, CF
catalog :
991-R2
quantity :
100 ug
price :
339 USD
citations: 14
Reference
Aljurayyan A, Puksuriwong S, Ahmed M, Sharma R, Krishnan M, Sood S, et al. Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response. J Virol. 2018;92: pubmed publisher
Désy O, Béland S, Vallin P, Riopel J, Latulippe E, Wagner E, et al. Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype. Sci Rep. 2018;8:4025 pubmed publisher
Kooy Winkelaar Y, Bouwer D, Janssen G, Thompson A, Brugman M, Schmitz F, et al. CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 2017;114:E980-E989 pubmed publisher
Zhang C, Gong Y, Zhu W, Qi Y, Yang C, Fu Y, et al. Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis. J Immunol. 2016;197:2610-7 pubmed publisher
Xing R, Yang L, Jin Y, Sun L, Li C, Li Z, et al. Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis. Scand J Immunol. 2016;83:64-71 pubmed publisher
Harker J, Wong K, Dolgoter A, Zuniga E. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015;195:1071-81 pubmed publisher
Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe J, et al. CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. J Immunol. 2015;194:3768-77 pubmed publisher
Vegran F, Berger H, Boidot R, Mignot G, Bruchard M, Dosset M, et al. The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells. Nat Immunol. 2014;15:758-66 pubmed publisher
Parmigiani A, Alcaide M, Freguja R, Pallikkuth S, Frasca D, Fischl M, et al. Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation. PLoS ONE. 2013;8:e79816 pubmed publisher
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A. Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol. 2013;131:1146-56, 1156.e1-5 pubmed publisher
Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, et al. Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J Immunol. 2010;184:2337-47 pubmed publisher
Eid R, Rao D, Zhou J, Lo S, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-32 pubmed publisher
Cerboni C, Ardolino M, Santoni A, Zingoni A. Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood. 2009;113:2955-64 pubmed publisher
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut. 2006;55:1774-80 pubmed
product information
brand :
R&D Systems
master code :
991-R2
SKU :
991-R2-100
product name :
Recombinant Human IL-21R Fc Chimera Protein, CF
description :
The Recombinant Human IL-21R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-21R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-21R
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
80-85 kDa, reducing conditions
theoretical molecular weight :
51.7 kDa (monomer)
gene symbol :
IL21R
details of functionality :
Measured by its ability to inhibit IL-21-dependent enhancement of IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is 40-400 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
991-R2
accessionNumbers :
Q9HBE5
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human IL-21R protein Human IL-21 R Subunit (Cys20-Pro236) Accession # Q9HBE5 DIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
extended description :
A New rh IL-21 R is Available! It is HEK293 expressed, exhibits enhanced activity, and has a His-tag.
2020 USD :
339
2021 USD :
339 USD
product details :
A New rh IL-21 R is Available! It is HEK293 expressed, exhibits enhanced activity, and has a His-tag.
alt names :
CD360, CD360 antigen, IL-21 R, IL-21 receptor, IL21R, IL-21R, interleukin 21 receptor, interleukin-21 receptor, MGC10967, NILR, Novel interleukin receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.