Recombinant Human IL-21R Fc Chimera Protein, CF | R&D Systems 991-R2-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-21R Fc Chimera Protein, CF

catalog :

991-R2-100

quantity :

100 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Chun J, Lim B, Roy S, Walsh M, Abhiraman G, Zhangxu K, et al. Potent antitumor activity of a designed interleukin-21 mimic. bioRxiv. 2024;: pubmed publisher
Szab xf3 K, J xe1 mbor I, P xe1 zm xe1 ndi K, Nagy N, Papp G, Tarr T. Altered Circulating Follicular T Helper Cell Subsets and Follicular T Regulatory Cells Are Indicators of a Derailed B Cell Response in Lupus, Which Could Be Modified by Targeting IL-21R. Int J Mol Sci. 2022;23: pubmed publisher
Janssen E, Tohme M, Butts J, Giguere S, Sage P, Velazquez F, et al. DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020;5: pubmed publisher
Aljurayyan A, Puksuriwong S, Ahmed M, Sharma R, Krishnan M, Sood S, et al. Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response. J Virol. 2018;92: pubmed publisher
DÃ©sy O, BÃ©land S, Vallin P, Riopel J, Latulippe E, Wagner E, et al. Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype. Sci Rep. 2018;8:4025 pubmed publisher
Kooy Winkelaar Y, Bouwer D, Janssen G, Thompson A, Brugman M, Schmitz F, et al. CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 2017;114:E980-E989 pubmed publisher
Zhang C, Gong Y, Zhu W, Qi Y, Yang C, Fu Y, et al. Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis. J Immunol. 2016;197:2610-7 pubmed publisher
Xing R, Yang L, Jin Y, Sun L, Li C, Li Z, et al. Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis. Scand J Immunol. 2016;83:64-71 pubmed publisher
Harker J, Wong K, Dolgoter A, Zuniga E. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015;195:1071-81 pubmed publisher
Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe J, et al. CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. J Immunol. 2015;194:3768-77 pubmed publisher
Parmigiani A, Alcaide M, Freguja R, Pallikkuth S, Frasca D, Fischl M, et al. Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation. PLoS ONE. 2013;8:e79816 pubmed publisher
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A. Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol. 2013;131:1146-56, 1156.e1-5 pubmed publisher
Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, et al. Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J Immunol. 2010;184:2337-47 pubmed publisher
Eid R, Rao D, Zhou J, Lo S, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-32 pubmed publisher
Cerboni C, Ardolino M, Santoni A, Zingoni A. Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood. 2009;113:2955-64 pubmed publisher
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut. 2006;55:1774-80 pubmed

product information

master code :

991-R2

SKU :

991-R2-100

product name :

Recombinant Human IL-21R Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Human IL-21R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-21R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-21R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

80-85 kDa, reducing conditions

theoretical molecular weight :

51.7 kDa (monomer)

gene symbol :

IL21R

details of functionality :

Measured by its ability to inhibit IL-21-dependent enhancement of IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is 40-400 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9HBE5

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human IL-21R protein Human IL-21 R Subunit (Cys20-Pro236) Accession # Q9HBE5 DIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

CD360, CD360 antigen, IL-21 R, IL-21 receptor, IL21R, IL-21R, interleukin 21 receptor, interleukin-21 receptor, MGC10967, NILR, Novel interleukin receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage