This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Amphiregulin Protein, CF
catalog :
989-AR-100/CF
quantity :
100 ug
price :
432 USD
citations: 21
Reference
Wang Y, Leng X, Zhou C, Lu S, Tsang C, Xu J, et al. Non-enzymatic role of SOD1 in intestinal stem cell growth. Cell Death Dis. 2022;13:882 pubmed publisher
von Joest M, Chen C, Douch xe9 T, Chantrel J, Chiche A, Gianetto Q, et al. Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming. Cell Rep. 2022;40:111074 pubmed publisher
Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, et al. Cardiac macrophages prevent sudden death during heart stress. Nat Commun. 2021;12:1910 pubmed publisher
Ko J, Kim H, Jeong H, Lee H, Oh J. Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis. Cell Rep. 2020;30:3806-3820.e6 pubmed publisher
Kubli S, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, et al. AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer. Proc Natl Acad Sci U S A. 2019;116:3604-3613 pubmed publisher
Mao S, Park M, Cabrera R, Christin J, Karagiannis G, Oktay M, et al. Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res. 2018;20:131 pubmed publisher
Koeppen M, Lee J, Seo S, Brodsky K, Kreth S, Yang I, et al. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018;9:816 pubmed publisher
Kitasaka H, Kawai T, Hoque S, Umehara T, Fujita Y, Shimada M. Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice. PLoS ONE. 2018;13:e0192458 pubmed publisher
Martin L, Smith S, Khoutorsky A, Magnussen C, Samoshkin A, Sorge R, et al. Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest. 2017;127:3353-3366 pubmed publisher
Taverna S, Pucci M, Giallombardo M, Di Bella M, Santarpia M, Reclusa P, et al. Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway. Sci Rep. 2017;7:3170 pubmed publisher
Venkataraman T, Coleman C, Frieman M. Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. J Virol. 2017;91: pubmed publisher
Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, et al. A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation. Nat Med. 2017;23:611-622 pubmed publisher
Jiang W, Song H, Li S, Guo B, Wu J, Li G, et al. Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia. EBioMedicine. 2017;17:134-144 pubmed publisher
Hall O, Limjunyawong N, Vermillion M, Robinson D, Wohlgemuth N, Pekosz A, et al. Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females. PLoS Pathog. 2016;12:e1005840 pubmed publisher
Ding L, Liu T, Wu Z, Hu B, Nakashima T, Ullenbruch M, et al. Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis. J Immunol. 2016;197:303-12 pubmed publisher
Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015;526:583-6 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Burzyn D, Kuswanto W, Kolodin D, Shadrach J, Cerletti M, Jang Y, et al. A special population of regulatory T cells potentiates muscle repair. Cell. 2013;155:1282-95 pubmed publisher
Pawar S, Starosvetsky E, Orvis G, Behringer R, Bagchi I, Bagchi M. STAT3 regulates uterine epithelial remodeling and epithelial-stromal crosstalk during implantation. Mol Endocrinol. 2013;27:1996-2012 pubmed publisher
Manzo N, Foster W, Stripp B. Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury. Am J Respir Cell Mol Biol. 2012;47:349-57 pubmed publisher
Monticelli L, Sonnenberg G, Abt M, Alenghat T, Ziegler C, Doering T, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011;12:1045-54 pubmed publisher
product information
master code :
989-AR/CF
SKU :
989-AR-100/CF
product name :
Recombinant Mouse Amphiregulin Protein, CF
unit size :
100 ug
description :
The Recombinant Mouse Amphiregulin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Amphiregulin Protein, CF has been validated for the following applications: Bioactivity.
target :
Amphiregulin
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
11.3 kDa
gene symbol :
Areg
details of functionality :
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Marquardt, H. et al . (1984) Science 223 :1079. The ED50 for this effect is 5-20 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q4FJT2
applications :
Bioactivity
source long :
E. coli -derived mouse Amphiregulin protein Ser94-Lys191
source short :
E. coli
USD :
432 USD
alt names :
amphiregulin, AR, AREG, AREGB, Colorectum cell-derived growth factor, CRDGF, MGC13647, schwannoma-derived growth factor, SDGF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.