Recombinant Mouse Gas6 Protein, CF | R&D Systems 986-GS-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Gas6 Protein, CF

catalog :

986-GS-025/CF

quantity :

25 ug

price :

509 USD

citations: 23

Reference
Owlett L, Karaahmet B, Le L, Belcher E, Dionisio Santos D, Olschowka J, et al. Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease. J Neuroinflammation. 2022;19:38 pubmed publisher
Zhou H, Hu L, Li J, Ruan W, Cao Y, Zhuang J, et al. AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury. J Neuroinflammation. 2021;18:154 pubmed publisher
Shibata T, Makino A, Ogata R, Nakamura S, Ito T, Nagata K, et al. Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization. J Clin Invest. 2020;130:3021-3037 pubmed publisher
Kurata A, Tachibana Y, Takahashi T, Horiba N. Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells. PLoS ONE. 2020;15:e0232055 pubmed publisher
Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, et al. A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. Cell Mol Gastroenterol Hepatol. 2020;9:349-368 pubmed publisher
Chirino L, Kumar S, Okumura M, Sterner D, Mattern M, Butt T, et al. TAM receptors attenuate murine NK-cell responses via E3 ubiquitin ligase Cbl-b. Eur J Immunol. 2020;50:48-55 pubmed publisher
Peng C, Wu C, Lin J, Peng S, Lee C, Huang K, et al. Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway. PLoS ONE. 2019;14:e0219788 pubmed publisher
Ni J, Lin M, Jin Y, Li J, Guo Y, Zhou J, et al. Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway. Front Pharmacol. 2019;10:662 pubmed publisher
Jung J, Lee Y, Choi Y, Park E, Kim H, Kang J. Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors. Cells. 2019;8: pubmed publisher
Jiang Y, Zhang Y, Leung J, Fan C, Popov K, Su S, et al. MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Nat Commun. 2019;10:1515 pubmed publisher
Gomes A, Carron E, Mills K, Dow A, Gray Z, Fecca C, et al. Stromal Gas6 promotes the progression of premalignant mammary cells. Oncogene. 2019;38:2437-2450 pubmed publisher
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
Lee Y, Park H, Woo S, Park E, Kang J. RhoA/phosphatidylinositol 3-kinase/protein kinase B/mitogen-activated protein kinase signaling after growth arrest-specific protein 6/mer receptor tyrosine kinase engagement promotes epithelial cell growth and wound repair via upregulation of hepatoc. J Pharmacol Exp Ther. 2014;350:563-77 pubmed publisher
Ji R, Tian S, Lu H, Lu Q, Zheng Y, Wang X, et al. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol. 2013;191:6165-77 pubmed publisher
Deng T, Zhang Y, Chen Q, Yan K, Han D. Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages. Immunology. 2012;135:40-50 pubmed publisher
Ye X, Li Y, Stawicki S, Couto S, Eastham Anderson J, Kallop D, et al. An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene. 2010;29:5254-64 pubmed publisher
Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, et al. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J Immunol. 2009;183:3004-13 pubmed publisher
Lafdil F, Chobert M, Deveaux V, Zafrani E, Mavier P, Nakano T, et al. Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. J Hepatol. 2009;51:55-66 pubmed publisher
Uehara H, Shacter E. Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells. J Immunol. 2008;180:2522-30 pubmed
Angelillo Scherrer A, Burnier L, Lambrechts D, Fish R, Tjwa M, Plaisance S, et al. Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest. 2008;118:583-96 pubmed publisher
Rothlin C, Ghosh S, Zuniga E, Oldstone M, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007;131:1124-36 pubmed
Sather S, Kenyon K, Lefkowitz J, Liang X, Varnum B, Henson P, et al. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood. 2007;109:1026-33 pubmed

product information

master code :

986-GS/CF

SKU :

986-GS-025/CF

product name :

Recombinant Mouse Gas6 Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse Gas6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Gas6 Protein, CF has been validated for the following applications: Binding Activity.

target :

Gas6

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

72 kDa, reducing conditions

theoretical molecular weight :

62 kDa

gene symbol :

Gas6

details of functionality :

Measured by its ability to down regulate the expression of Axl in DU145 human prostate carcinoma cells. Mishra, A. etáal . (2012) Mol. Cancer Res. 10 :703. The ED50 for this effect is 20-100 ng/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

CAA42507

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse Gas6 protein Asp115-Pro673, with a C-terminal 6-His tag

source short :

NS0

USD :

509 USD

alt names :

AXLLG, AXLLGAXL stimulatory factor, AXSFAXL receptor tyrosine kinase ligand, DKFZp666G247, FLJ34709, GAS-6, growth arrest-specific 6, growth arrest-specific protein 6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.