Recombinant Mouse TIMP-1 Protein, CF | R&D Systems 980-MT-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TIMP-1 Protein, CF

catalog :

980-MT-010

quantity :

10 ug

price :

480 USD

more info or order :

R&D Systems product webpage

citations: 13

Reference
Priego N, de Pablos Aragoneses A, Perea Garc xed a M, Pieri V, Hern xe1 ndez Oliver C, xc1 lvaro Espinosa L, et al. TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells. Cancer Discov. 2025;15:179-201 pubmed publisher
Nakamura K, Tsukasaki M, Tsunematsu T, Yan M, Ando Y, Huynh N, et al. The periosteum provides a stromal defence against cancer invasion into the bone. Nature. 2024;634:474-481 pubmed publisher
Liou G, Fleming Martinez A, D xf6 ppler H, Bastea L, Storz P. Inflammatory and alternatively activated macrophages independently induce metaplasia but cooperatively drive pancreatic precancerous lesion growth. iScience. 2023;26:106820 pubmed publisher
Sutter P, Willis C, Menoret A, Nicaise A, Sacino A, Sikkema A, et al. Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responses. bioRxiv. 2023;: pubmed publisher
Girardi F, Taleb A, Ebrahimi M, Datye A, Gamage D, Peccate C, et al. TGFβ signaling curbs cell fusion and muscle regeneration. Nat Commun. 2021;12:750 pubmed publisher
Wang X, Rojas Quintero J, Wilder J, Tesfaigzi Y, Zhang D, Owen C. Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces. J Immunol. 2019;202:3267-3281 pubmed publisher
Martin L, Smith S, Khoutorsky A, Magnussen C, Samoshkin A, Sorge R, et al. Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest. 2017;127:3353-3366 pubmed publisher
Strålberg F, Kassem A, Kasprzykowski F, Abrahamson M, Grubb A, Lindholm C, et al. Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc Biol. 2017;101:1233-1243 pubmed publisher
Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, et al. Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities. PLoS ONE. 2014;9:e103839 pubmed publisher
Mannaerts I, Schroyen B, Verhulst S, Van Lommel L, Schuit F, Nyssen M, et al. Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration. PLoS ONE. 2013;8:e84071 pubmed publisher
Strålberg F, Henning P, Gjertsson I, Kindlund B, Souza P, Persson E, et al. Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling. FASEB J. 2013;27:2687-701 pubmed publisher
Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, et al. Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance. Am J Physiol Lung Cell Mol Physiol. 2010;298:L67-78 pubmed publisher
Ogier C, Bernard A, Chollet A, Le Diguardher T, Hanessian S, Charton G, et al. Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia. 2006;54:272-84 pubmed

product information

brand :

R&D Systems

master code :

980-MT

SKU :

980-MT-010

product name :

Recombinant Mouse TIMP-1 Protein, CF

unit size :

10 ug

seo description :

The Recombinant Mouse TIMP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TIMP-1 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

TIMP-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

dilution :

Inhibition Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

32 kDa, reducing conditions

theoretical molecular weight :

20 kDa

gene symbol :

Timp1

details of functionality :

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is 3.5 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P12032

applications :

Inhibition Activity

source :

NS0-derived Recombinant Mouse TIMP-1 Protein, CF

USD :

480 USD

alt names :

CLGI, Collagenase inhibitor, collagenase inhibitor), EPATIMP-1, EPO, erythroid potentiating activity, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, metalloproteinase inhibitor 1, TIMP metallopeptidase inhibitor 1, TIMP1, TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, Tissue inhibitor of metalloproteinases 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage