Recombinant Human TIMP-4 (Sf 21-expressed) Protein, CF | R&D Systems 974-TSF-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TIMP-4 (Sf 21-expressed) Protein, CF

catalog :

974-TSF-010

quantity :

10 ug

price :

491 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Minns A, Qi Y, Yamamoto K, Lee K, Ahnstr xf6 m J, Santamaria S. The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity. J Biol Chem. 2023;299:103048 pubmed publisher
Santamaria S, Martin D, Dong X, Yamamoto K, Apte S, Ahnstr xf6 m J. Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. J Biol Chem. 2021;297:101323 pubmed publisher
Nielsen M, Andersen M, Rittig N, Rødgaard Hansen S, Grønbaek H, Moestrup S, et al. The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms. J Leukoc Biol. 2019;106:1129-1138 pubmed publisher
Wong K, Zhu F, Khatri I, Huo Q, Spaner D, Gorczynski R. Characterization of CD200 Ectodomain Shedding. PLoS ONE. 2016;11:e0152073 pubmed publisher
Lizarraga F, Ceballos Cancino G, Espinosa M, Vazquez Santillan K, Maldonado V, Melendez Zajgla J. Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells. PLoS ONE. 2015;10:e0135929 pubmed publisher
Golubkov V, Strongin A. Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7). J Biol Chem. 2012;287:42009-18 pubmed publisher
Sun Q, Weber C, Sohail A, Bernardo M, Toth M, Zhao H, et al. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. J Biol Chem. 2007;282:21998-2010 pubmed

product information

brand :

R&D Systems

master code :

974-TSF

SKU :

974-TSF-010

product name :

Recombinant Human TIMP-4 (Sf 21-expressed) Protein, CF

unit size :

10 ug

seo description :

The Recombinant Human TIMP-4 (Sf 21-expressed) Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human TIMP-4 (Sf 21-expressed) Protein, CF has been validated for the following applications: Inhibition Activity.

target :

TIMP-4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

dilution :

Inhibition Activity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

23 kDa, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

TIMP4

details of functionality :

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is approximately 2.5 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q99727

applications :

Inhibition Activity

source :

Sf 21 (baculovirus)-derived Recombinant Human TIMP-4 (Sf 21-expressed) Protein, CF

USD :

491 USD

alt names :

metalloproteinase inhibitor 4, TIMP metallopeptidase inhibitor 4, TIMP4, TIMP-4, tissue inhibitor of metalloproteinase 4, Tissue inhibitor of metalloproteinases 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage