Recombinant Human TIMP-2 Protein, CF | R&D Systems 971-TM product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TIMP-2 Protein, CF

catalog :

971-TM

quantity :

10 ug

price :

429 USD

citations: 7

Reference
Kumar J, Aolymat I, Tiszlavicz L, Reisz Z, Garalla H, Beynon R, et al. Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget. 2019;10:98-112 pubmed publisher
Wong K, Zhu F, Khatri I, Huo Q, Spaner D, Gorczynski R. Characterization of CD200 Ectodomain Shedding. PLoS ONE. 2016;11:e0152073 pubmed publisher
Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, et al. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine. 2015;71:238-45 pubmed publisher
Yang S, Cody J, Rivera A, Waehler R, Wang M, Kimball K, et al. Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy. Clin Cancer Res. 2011;17:538-49 pubmed publisher
Goldoni S, Humphries A, Nyström A, Sattar S, Owens R, McQuillan D, et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009;185:743-54 pubmed publisher
Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, et al. MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization. J Clin Invest. 2009;119:492-503 pubmed publisher
Ogier C, Bernard A, Chollet A, Le Diguardher T, Hanessian S, Charton G, et al. Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia. 2006;54:272-84 pubmed

product information

brand :

R&D Systems

master code :

971-TM

SKU :

971-TM-010

product name :

Recombinant Human TIMP-2 Protein, CF

description :

The Recombinant Human TIMP-2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human TIMP-2 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

TIMP-2

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

22-23 kDa, reducing conditions

theoretical molecular weight :

21 kDa

gene symbol :

TIMP2

details of functionality :

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is approximately 2.2 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

971-TM

accessionNumbers :

P16035

applications :

Inhibition Activity

source :

Chinese Hamster Ovary cell line, CHO-derived human TIMP-2 protein Cys27-Pro220

2020 USD :

429

2021 USD :

429 USD

alt names :

CSC-21Ktissue inhibitor of metalloproteinase 2, metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, TIMP2, TIMP-2, Tissue inhibitor of metalloproteinases 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.