product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TIMP-2 Protein, CF
catalog :
971-TM-010
quantity :
10 ug
price :
525 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Peng J, Lin Z, Chen W, Ruan J, Deng F, Yao L, et al. Vemurafenib induces a noncanonical senescence-associated secretory phenotype in melanoma cells which promotes vemurafenib resistance. Heliyon. 2023;9:e17714 pubmed publisher
Knapinska A, Drotleff G, Chai C, Twohill D, Ernce A, Tokmina Roszyk D, et al. Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids. Biomedicines. 2023;11: pubmed publisher
Minns A, Qi Y, Yamamoto K, Lee K, Ahnstr xf6 m J, Santamaria S. The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity. J Biol Chem. 2023;299:103048 pubmed publisher
Santamaria S, Martin D, Dong X, Yamamoto K, Apte S, Ahnstr xf6 m J. Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. J Biol Chem. 2021;297:101323 pubmed publisher
Kumar J, Aolymat I, Tiszlavicz L, Reisz Z, Garalla H, Beynon R, et al. Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget. 2019;10:98-112 pubmed publisher
Wong K, Zhu F, Khatri I, Huo Q, Spaner D, Gorczynski R. Characterization of CD200 Ectodomain Shedding. PLoS ONE. 2016;11:e0152073 pubmed publisher
Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, et al. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine. 2015;71:238-45 pubmed publisher
Yang S, Cody J, Rivera A, Waehler R, Wang M, Kimball K, et al. Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy. Clin Cancer Res. 2011;17:538-49 pubmed publisher
Goldoni S, Humphries A, Nyström A, Sattar S, Owens R, McQuillan D, et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009;185:743-54 pubmed publisher
Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, et al. MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization. J Clin Invest. 2009;119:492-503 pubmed publisher
Ogier C, Bernard A, Chollet A, Le Diguardher T, Hanessian S, Charton G, et al. Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia. 2006;54:272-84 pubmed
product information
brand :
R&D Systems
master code :
971-TM
SKU :
971-TM-010
product name :
Recombinant Human TIMP-2 Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human TIMP-2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human TIMP-2 Protein, CF has been validated for the following applications: Inhibition Activity.
target :
TIMP-2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.
conjugate :
Unconjugated
dilution :
Inhibition Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
22-23 kDa, reducing conditions
theoretical molecular weight :
21 kDa
gene symbol :
TIMP2
details of functionality :
Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is approximately 2.2 nM, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P16035
applications :
Inhibition Activity
source :
CHO-derived Recombinant Human TIMP-2 Protein, CF
USD :
525 USD
alt names :
CSC-21Ktissue inhibitor of metalloproteinase 2, metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, TIMP2, TIMP-2, Tissue inhibitor of metalloproteinases 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.