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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TIMP-1 Protein, CF
catalog :
970-TM-010
quantity :
10 ug
price :
444 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Minns A, Qi Y, Yamamoto K, Lee K, Ahnstr xf6 m J, Santamaria S. The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity. J Biol Chem. 2023;299:103048 pubmed publisher
Chintala S, Pan J, Satapathy S, Condruti R, Hao Z, Liu P, et al. Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy. Int J Mol Sci. 2023;24: pubmed publisher
Larrouture Q, Cribbs A, Rao S, Philpott M, Snelling S, Knowles H. Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs. Sci Rep. 2021;11:22708 pubmed publisher
Santamaria S, Martin D, Dong X, Yamamoto K, Apte S, Ahnstr xf6 m J. Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. J Biol Chem. 2021;297:101323 pubmed publisher
Mirastschijski U, Lupse B, Maedler K, Sarma B, Radtke A, Belge G, et al. Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin. Int J Mol Sci. 2019;20: pubmed publisher
Kumar J, Aolymat I, Tiszlavicz L, Reisz Z, Garalla H, Beynon R, et al. Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget. 2019;10:98-112 pubmed publisher
Wong K, Zhu F, Khatri I, Huo Q, Spaner D, Gorczynski R. Characterization of CD200 Ectodomain Shedding. PLoS ONE. 2016;11:e0152073 pubmed publisher
Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, et al. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine. 2015;71:238-45 pubmed publisher
Ågren M, Schnabel R, Christensen L, Mirastschijski U. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. Eur J Cell Biol. 2015;94:12-21 pubmed publisher
Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, et al. Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1. Biochem J. 2015;465:259-70 pubmed publisher
Vinther L, Lademann U, Andersen E, Højrup P, Thaysen Andersen M, Krogh B, et al. Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells. Protein Expr Purif. 2014;101:157-64 pubmed publisher
Tinnes S, Ringwald J, Haas C. TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy. FASEB J. 2013;27:2542-52 pubmed publisher
Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia. 2011;54:1468-79 pubmed publisher
Schipper H, de Jager W, van Dijk M, Meerding J, Zelissen P, Adan R, et al. A multiplex immunoassay for human adipokine profiling. Clin Chem. 2010;56:1320-8 pubmed publisher
Goldoni S, Humphries A, Nyström A, Sattar S, Owens R, McQuillan D, et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009;185:743-54 pubmed publisher
Nicol G, Han M, Kim J, Birse C, Brand E, Nguyen A, et al. Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients. Mol Cell Proteomics. 2008;7:1974-82 pubmed publisher
Anghelina M, Krishnan P, Moldovan L, Moldovan N. Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am J Pathol. 2006;168:529-41 pubmed
Djafarzadeh R, Noessner E, Engelmann H, Schendel D, Notohamiprodjo M, von Luettichau I, et al. GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing. Oncogene. 2006;25:1496-508 pubmed
Von Tresckow B, Kallen K, Von Strandmann E, Borchmann P, Lange H, Engert A, et al. Depletion of cellular cholesterol and lipid rafts increases shedding of CD30. J Immunol. 2004;172:4324-31 pubmed
product information
brand :
R&D Systems
master code :
970-TM
SKU :
970-TM-010
product name :
Recombinant Human TIMP-1 Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human TIMP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TIMP-1 Protein, CF has been validated for the following applications: Inhibition Activity.
target :
TIMP-1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Sodium Acetate and NaCl.
conjugate :
Unconjugated
dilution :
Inhibition Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
28-30 kDa, reducing conditions
theoretical molecular weight :
21 kDa
gene symbol :
TIMP1
details of functionality :
Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is approximately 2.5 nM as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q6FGX5
applications :
Inhibition Activity
source :
NS0-derived Recombinant Human TIMP-1 Protein, CF
USD :
444 USD
alt names :
CLGI, Collagenase inhibitor, collagenase inhibitor), EPATIMP-1, EPO, erythroid potentiating activity, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, metalloproteinase inhibitor 1, TIMP metallopeptidase inhibitor 1, TIMP1, TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, Tissue inhibitor of metalloproteinases 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.