Recombinant Mouse Cathepsin B Protein, CF | R&D Systems 965-CY-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Cathepsin B Protein, CF

catalog :

965-CY-010

quantity :

10 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Cho H, Shim M, Moon Y, Song S, KIM J, Choi J, et al. Tumor-Specific Monomethyl Auristatin E (MMAE) Prodrug Nanoparticles for Safe and Effective Chemotherapy. Pharmaceutics. 2022;14: pubmed publisher
Duarte C, Yamada C, Garcia C, Akkaoui J, Ho A, Nichols F, et al. Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis. J Cell Mol Med. 2022;26:2841-2851 pubmed publisher
Demcsák A, Geisz A, Sahin Toth M. Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B. Sci Rep. 2019;9:9188 pubmed publisher
Tran A, Sundar S, Yu M, Lang B, Silver J. Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth. J Neurosci. 2018;38:5399-5414 pubmed publisher
McComb S, Shutinoski B, Thurston S, Cessford E, Kumar K, Sad S. Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. J Immunol. 2014;192:5671-8 pubmed publisher
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Vegran F, et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 2013;19:57-64 pubmed publisher
Chang S, Kanasaki K, Gocheva V, Blum G, Harper J, Moses M, et al. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res. 2009;69:4537-44 pubmed publisher

product information

brand :

R&D Systems

master code :

965-CY

SKU :

965-CY-010

product name :

Recombinant Mouse Cathepsin B Protein, CF

unit size :

10 ug

seo description :

The Recombinant Mouse Cathepsin B Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Cathepsin B Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Cathepsin B

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

43 kDa, reducing conditions

theoretical molecular weight :

37 kDa

gene symbol :

Ctsb

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (Catalog # ES008 ). The specific activity is 2,000 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P10605

applications :

Enzyme Activity

source :

NS0-derived Recombinant Mouse Cathepsin B Protein, CF

USD :

432 USD

alt names :

APP secretase, APPS, cathepsin B, Cathepsin B1, CPSBamyloid precursor protein secretase, CTSB, cysteine protease, EC 3.4.22, EC 3.4.22.1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage