Recombinant Human GDF-15 (CHO-expressed) Protein | R&D Systems 957-GD product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human GDF-15 (CHO-expressed) Protein

catalog :

957-GD

quantity :

25 ug

price :

349 USD

citations: 25

Reference
Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, et al. Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma. Endocr J. 2020;67:91-94 pubmed publisher
Melvin A, Lacerda E, Dockrell H, O Rahilly S, Nacul L. Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome. J Transl Med. 2019;17:409 pubmed publisher
Gkretsi V, Louca M, Stylianou A, Minadakis G, Spyrou G, Stylianopoulos T. Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15). Int J Mol Sci. 2019;20: pubmed publisher
Jung S, Choi M, Ryu D, Yi H, Lee S, Chang J, et al. Reduced oxidative capacity in macrophages results in systemic insulin resistance. Nat Commun. 2018;9:1551 pubmed publisher
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Sasahara A, Tominaga K, Nishimura T, Yano M, Kiyokawa E, Noguchi M, et al. An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells. Oncotarget. 2017;8:24869-24881 pubmed publisher
Muralidharan A, Maddala R, Skiba N, Rao P. Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2016;57:6482-6495 pubmed publisher
Li Y, Chang J, Lee L, Fan K, Lu Y, Li Y, et al. GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway. Oncotarget. 2017;8:1508-1528 pubmed publisher
Maetzler W, Deleersnijder W, Hanssens V, Bernard A, Brockmann K, Marquetand J, et al. GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia. PLoS ONE. 2016;11:e0149349 pubmed publisher
Li J, Veltri R, Yuan Z, Christudass C, Mandecki W. Macrophage inhibitory cytokine 1 biomarker serum immunoassay in combination with PSA is a more specific diagnostic tool for detection of prostate cancer. PLoS ONE. 2015;10:e0122249 pubmed publisher
Zhou Z, Li W, Song Y, Wang L, Zhang K, Yang J, et al. Growth differentiation factor-15 suppresses maturation and function of dendritic cells and inhibits tumor-specific immune response. PLoS ONE. 2013;8:e78618 pubmed publisher
Mimeault M, Johansson S, Batra S. Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1. Br J Cancer. 2013;108:1079-91 pubmed publisher
Rossaint J, Vestweber D, Zarbock A. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost. 2013;11:335-44 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Si Y, Liu X, Cheng M, Wang M, Gong Q, Yang Y, et al. Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes. PLoS ONE. 2011;6:e19967 pubmed publisher
Cheng J, Chang H, Leung P. Wild-type p53 attenuates cancer cell motility by inducing growth differentiation factor-15 expression. Endocrinology. 2011;152:2987-95 pubmed publisher
Schledzewski K, Géraud C, Arnold B, Wang S, Grone H, Kempf T, et al. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011;121:703-14 pubmed publisher
Huh S, Chung C, Sharma A, Robertson G. Macrophage inhibitory cytokine-1 regulates melanoma vascular development. Am J Pathol. 2010;176:2948-57 pubmed publisher
Xue H, Lu B, Zhang J, Wu M, Huang Q, Wu Q, et al. Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach. J Proteome Res. 2010;9:545-55 pubmed publisher
Strelau J, Strzelczyk A, Rusu P, Bendner G, Wiese S, Diella F, et al. Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci. 2009;29:13640-8 pubmed publisher
Foley P, Stegemann B, Ng K, Ramachandran S, Proudler A, Frenneaux M, et al. Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy. Eur Heart J. 2009;30:2749-57 pubmed publisher
Khan S, Ng K, Dhillon O, Kelly D, Quinn P, Squire I, et al. Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction. Eur Heart J. 2009;30:1057-65 pubmed publisher
Ding Q, Mracek T, Gonzalez Muniesa P, Kos K, Wilding J, Trayhurn P, et al. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009;150:1688-96 pubmed publisher
Tanno T, Bhanu N, Oneal P, Goh S, Staker P, Lee Y, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13:1096-101 pubmed
Wollert K, Kempf T, Peter T, Olofsson S, James S, Johnston N, et al. Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome. Circulation. 2007;115:962-71 pubmed

product information

brand :

R&D Systems

master code :

957-GD

SKU :

957-GD-025

product name :

Recombinant Human GDF-15 (CHO-expressed) Protein

description :

The Recombinant Human GDF-15 (CHO-expressed) Protein from R&D Systems is derived from CHO. The Recombinant Human GDF-15 (CHO-expressed) Protein has been validated for the following applications: Bioactivity not tested.

target :

GDF-15

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

14 kDa, reducing conditions

theoretical molecular weight :

13 kDa (monomer)

gene symbol :

GDF15

details of functionality :

Measured by its ability to activate SRE-SEAP reporter in HEK293 human embryonic kidney cells transfected with human c-Ret and human GFRAL. The ED50 for this effect is 0.4-4 ng/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

957-GD

accessionNumbers :

Q99988

applications :

Bioactivity not tested

source :

Chinese Hamster Ovary cell line, CHO-derived human GDF-15 protein Ala197-Ile308, with an N-terminal 6-His tag

extended description :

A New rh GDF-15 is Now Available! E. coli-expressed; Lower endotoxin specification; Competitively priced!

2020 USD :

349

2021 USD :

349 USD

product details :

A New rh GDF-15 is Now Available! E. coli-expressed; Lower endotoxin specification; Competitively priced!

alt names :

GDF15, growth differentiation factor 15, growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC-1, MIC-1NSAID-activated gene 1 protein, MIC1Prostate differentiation factor, NAG-1, NAG-1NSAID-regulated gene 1 protein, NSAID (nonsteroidal inflammatory drug)-activated protein 1, PDF, PDFGDF-15, PLAB, PLABNRG-1, Placental bone morphogenetic protein, Placental TGF-beta, PTGF-beta, PTGFBPTGF-beta

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.