product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human GDF-15 (CHO-expressed) Protein
catalog :
957-GD-025
quantity :
25 ug
price :
420 USD
more info or order :
R&D Systems product webpage
citations: 29
Reference
Wei W, Lyu X, Markhard A, Fu S, Mardjuki R, Cavanagh P, et al. A PTER-dependent pathway of taurine metabolism linked to energy balance. bioRxiv. 2024;: pubmed publisher
Xiao S, Li V, Lyu X, Chen X, Wei W, Abbasi F, et al. Lac-Phe mediates the anti-obesity effect of metformin. bioRxiv. 2023;: pubmed publisher
Alexopoulou F, Buch M xe5 nson N, Pedersen S, Vrang N, Fink L, Str xf8 mgaard K. Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling. Peptides. 2023;168:171063 pubmed publisher
Newman S, Wilson B, Mamerow D, Wollant B, Nyein H, Rosenberg Hasson Y, et al. Extending the dynamic range of biomarker quantification through molecular equalization. Nat Commun. 2023;14:4192 pubmed publisher
Zhang C, Vincelette L, Reimann F, Liberles S. A brainstem circuit for nausea suppression. Cell Rep. 2022;39:110953 pubmed publisher
Melvin A, Lacerda E, Dockrell H, O Rahilly S, Nacul L. Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome. J Transl Med. 2019;17:409 pubmed publisher
Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, et al. Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma. Endocr J. 2020;67:91-94 pubmed publisher
Gkretsi V, Louca M, Stylianou A, Minadakis G, Spyrou G, Stylianopoulos T. Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15). Int J Mol Sci. 2019;20: pubmed publisher
Jung S, Choi M, Ryu D, Yi H, Lee S, Chang J, et al. Reduced oxidative capacity in macrophages results in systemic insulin resistance. Nat Commun. 2018;9:1551 pubmed publisher
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Sasahara A, Tominaga K, Nishimura T, Yano M, Kiyokawa E, Noguchi M, et al. An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells. Oncotarget. 2017;8:24869-24881 pubmed publisher
Muralidharan A, Maddala R, Skiba N, Rao P. Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2016;57:6482-6495 pubmed publisher
Li Y, Chang J, Lee L, Fan K, Lu Y, Li Y, et al. GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway. Oncotarget. 2017;8:1508-1528 pubmed publisher
Maetzler W, Deleersnijder W, Hanssens V, Bernard A, Brockmann K, Marquetand J, et al. GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia. PLoS ONE. 2016;11:e0149349 pubmed publisher
Li J, Veltri R, Yuan Z, Christudass C, Mandecki W. Macrophage inhibitory cytokine 1 biomarker serum immunoassay in combination with PSA is a more specific diagnostic tool for detection of prostate cancer. PLoS ONE. 2015;10:e0122249 pubmed publisher
Zhou Z, Li W, Song Y, Wang L, Zhang K, Yang J, et al. Growth differentiation factor-15 suppresses maturation and function of dendritic cells and inhibits tumor-specific immune response. PLoS ONE. 2013;8:e78618 pubmed publisher
Mimeault M, Johansson S, Batra S. Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1. Br J Cancer. 2013;108:1079-91 pubmed publisher
Rossaint J, Vestweber D, Zarbock A. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost. 2013;11:335-44 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Si Y, Liu X, Cheng M, Wang M, Gong Q, Yang Y, et al. Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes. PLoS ONE. 2011;6:e19967 pubmed publisher
Cheng J, Chang H, Leung P. Wild-type p53 attenuates cancer cell motility by inducing growth differentiation factor-15 expression. Endocrinology. 2011;152:2987-95 pubmed publisher
Schledzewski K, Géraud C, Arnold B, Wang S, Grone H, Kempf T, et al. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011;121:703-14 pubmed publisher
Huh S, Chung C, Sharma A, Robertson G. Macrophage inhibitory cytokine-1 regulates melanoma vascular development. Am J Pathol. 2010;176:2948-57 pubmed publisher
Strelau J, Strzelczyk A, Rusu P, Bendner G, Wiese S, Diella F, et al. Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci. 2009;29:13640-8 pubmed publisher
Foley P, Stegemann B, Ng K, Ramachandran S, Proudler A, Frenneaux M, et al. Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy. Eur Heart J. 2009;30:2749-57 pubmed publisher
Khan S, Ng K, Dhillon O, Kelly D, Quinn P, Squire I, et al. Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction. Eur Heart J. 2009;30:1057-65 pubmed publisher
Ding Q, Mracek T, Gonzalez Muniesa P, Kos K, Wilding J, Trayhurn P, et al. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009;150:1688-96 pubmed publisher
Tanno T, Bhanu N, Oneal P, Goh S, Staker P, Lee Y, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13:1096-101 pubmed
Wollert K, Kempf T, Peter T, Olofsson S, James S, Johnston N, et al. Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome. Circulation. 2007;115:962-71 pubmed
product information
brand :
R&D Systems
master code :
957-GD
SKU :
957-GD-025
product name :
Recombinant Human GDF-15 (CHO-expressed) Protein
unit size :
25 ug
seo description :
The Recombinant Human GDF-15 (CHO-expressed) Protein from R&D Systems is derived from CHO. The Recombinant Human GDF-15 (CHO-expressed) Protein has been validated for the following applications: Bioactivity not tested.
target :
GDF-15
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity not tested
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
14 kDa, reducing conditions
theoretical molecular weight :
13 kDa (monomer)
gene symbol :
GDF15
details of functionality :
Measured by its binding ability in a functional ELISA. Recombinant Human GDF-15 (Catalog # 957-GD) binds to Recombinant Human GFR alpha -like Fc Chimera (Catalog # 9697-GR ) with an ED50 of 0.0600-0.600 ng/mL.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q99988
applications :
Bioactivity not tested
source :
CHO-derived Recombinant Human GDF-15 (CHO-expressed) Protein
USD :
420 USD
alt names :
GDF15, growth differentiation factor 15, growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC-1, MIC-1NSAID-activated gene 1 protein, MIC1Prostate differentiation factor, NAG-1, NAG-1NSAID-regulated gene 1 protein, NSAID (nonsteroidal inflammatory drug)-activated protein 1, PDF, PDFGDF-15, PLAB, PLABNRG-1, Placental bone morphogenetic protein, Placental TGF-beta, PTGF-beta, PTGFBPTGF-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.