Recombinant Mouse Gremlin Protein, CF | R&D Systems 956-GR-050/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Gremlin Protein, CF

catalog :

956-GR-050/CF

quantity :

50 ug

price :

405 USD

citations: 11

Reference
P xe9 rez Lozano M, Sudre L, van Eegher S, Citadelle D, Pigenet A, Lafage Proust M, et al. Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes. Int J Mol Sci. 2022;23: pubmed publisher
Khatib Shahidi R, M Hoffmann J, Hedjazifar S, Bonnet L, K Baboota R, Heasman S, et al. Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver. PLoS ONE. 2021;16:e0247300 pubmed publisher
Meng L, Teng X, Liu Y, Yang C, Wang S, Yuan W, et al. Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts. J Am Heart Assoc. 2020;9:e016586 pubmed publisher
Mata Miranda M, Vazquez Zapien G, Rojas Lopez M, Sánchez Monroy V, Pérez Ishiwara D, Delgado Macuil R. Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells. Biol Res. 2017;50:14 pubmed publisher
Ahmed K, Lapierre M, Gasser E, Denzler R, Yang Y, Rülicke T, et al. Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility. J Clin Invest. 2017;127:1061-1074 pubmed publisher
Tatsinkam A, Rune N, Smith J, Norman J, Mulloy B, Rider C. The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism. Int J Biochem Cell Biol. 2017;83:39-46 pubmed publisher
Davies J, Hohenstein P, Chang C, Berry R. A self-avoidance mechanism in patterning of the urinary collecting duct tree. BMC Dev Biol. 2014;14:35 pubmed publisher
Corsini M, Moroni E, Ravelli C, Andres G, Grillo E, Ali I, et al. Cyclic adenosine monophosphate-response element-binding protein mediates the proangiogenic or proinflammatory activity of gremlin. Arterioscler Thromb Vasc Biol. 2014;34:136-45 pubmed publisher
Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, et al. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009;184:597-609 pubmed publisher
Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, et al. Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood. 2007;109:1834-40 pubmed
Greber B, Lehrach H, Adjaye J. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells. 2007;25:455-64 pubmed

product information

brand :

R&D Systems

master code :

956-GR/CF

SKU :

956-GR-050/CF

product name :

Recombinant Mouse Gremlin Protein, CF

description :

The Recombinant Mouse Gremlin Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Gremlin Protein, CF has been validated for the following applications: Bioactivity.

target :

Gremlin

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

23-31 kDa, reducing conditions

theoretical molecular weight :

19.6 kDa

gene symbol :

Grem1

details of functionality :

Measured by its ability to inhibit alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.025-0.15 µg/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O70326

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Gremlin Protein, CF

USD :

405 USD

alt names :

Cell proliferation-inducing gene 2 protein, CKTSF1B1gremlin 1, cysteine knot superfamily, homolog, Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis), DAN domain family member 2, DAND2, DAND2GREMLIN, Down-regulated in Mos-transformed cells protein, DRM, DRMMGC126660, GREM1, gremlin, gremlin 1, gremlin 1-like protein, gremlin-1, IHG-2, Increased in high glucose protein 2, increased in high glucose-2, proliferation-inducing gene 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.