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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Cathepsin B Protein, CF
catalog :
953-CY-010
quantity :
10 ug
price :
432 USD
more info or order :
citations: 16
Reference
Kim J, Song S, Gwak M, Cho H, Yun W, Hwang N, et al. Micro-syringe chip-guided intratumoral administration of lipid nanoparticles for targeted anticancer therapy. Biomater Res. 2023;27:102 pubmed publisher
Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, et al. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022;602:496-502 pubmed publisher
Wu Y, Whittaker H, Noy S, Cleverley K, Brault V, Herault Y, et al. The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model. PLoS ONE. 2021;16:e0242236 pubmed publisher
Adem S, Jain S, Sveiven M, Zhou X, O Donoghue A, Hall D. Giant magnetoresistive biosensors for real-time quantitative detection of protease activity. Sci Rep. 2020;10:7941 pubmed publisher
Høglund R, Torsetnes S, Lossius A, Bogen B, Homan E, BREMEL R, et al. Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner. Int J Mol Sci. 2019;20: pubmed publisher
Huo D, Zhu J, Chen G, Chen Q, Zhang C, Luo X, et al. Eradication of unresectable liver metastasis through induction of tumour specific energy depletion. Nat Commun. 2019;10:3051 pubmed publisher
Leguizamón N, Rodrigues E, de Campos M, Nogueira A, Viola K, Schneider V, et al. In vivo and in vitro anti-inflammatory and pro-osteogenic effects of citrus cystatin CsinCPI-2. Cytokine. 2019;123:154760 pubmed publisher
Lee C, Stankowski J, Chew J, Cook C, Lam Y, Almeida S, et al. The lysosomal protein cathepsin L is a progranulin protease. Mol Neurodegener. 2017;12:55 pubmed publisher
Larimer B, Wehrenberg Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K, et al. Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response. Cancer Res. 2017;77:2318-2327 pubmed publisher
Shivanna V, Kim Y, Chang K. Endosomal acidification and cathepsin L activity is required for calicivirus replication. Virology. 2014;464-465:287-295 pubmed publisher
Jiang H, Cheng X, Shi G, Hu L, Inoue A, Yamamura Y, et al. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nat Commun. 2014;5:3838 pubmed publisher
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Vegran F, et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 2013;19:57-64 pubmed publisher
Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, et al. Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood. 2011;118:4694-704 pubmed publisher
Burster T, Marin Esteban V, Boehm B, Dunn S, Rotzschke O, Falk K, et al. Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions. Biochem Pharmacol. 2007;74:1514-23 pubmed
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, et al. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006;20:543-56 pubmed
product information
brand :
R&D Systems
master code :
953-CY
SKU :
953-CY-010
product name :
Recombinant Human Cathepsin B Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human Cathepsin B Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin B Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Cathepsin B
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in Tris and NaCl.
conjugate :
Unconjugated
dilution :
Enzyme Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
43 kDa and 36 kDa, reducing conditions
theoretical molecular weight :
37 kDa (Pro) 29 kDa (Mature)
gene symbol :
CTSB
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (Catalog # ES008 ). The specific activity is 2,500 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P07858
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Cathepsin B Protein, CF
USD :
432 USD
alt names :
APP secretase, APPS, cathepsin B, Cathepsin B1, CPSBamyloid precursor protein secretase, CTSB, cysteine protease, EC 3.4.22, EC 3.4.22.1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.