Recombinant Mouse ADAM10 Protein, CF | R&D Systems 946-AD-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse ADAM10 Protein, CF

catalog :

946-AD-020

quantity :

20 ug

price :

618 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Burmeister M, Frauenstein A, Kahms M, Arends L, Gerwien H, Deshpande T, et al. Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function. Sci Adv. 2023;9:eadg0686 pubmed publisher
Aung A, Cui A, Maiorino L, Amini A, Gregory J, Bukenya M, et al. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science. 2023;379:eabn8934 pubmed publisher
Kanzaki H, Shinohara F, Suzuki M, Wada S, Miyamoto Y, Yamaguchi Y, et al. A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma. Sci Rep. 2016;6:32259 pubmed publisher
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed

product information

master code :

946-AD

SKU :

946-AD-020

product name :

Recombinant Mouse ADAM10 Protein, CF

unit size :

20 ug

description :

The Recombinant Mouse ADAM10 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse ADAM10 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAM10

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in MES, NaCl, CaCl2, ZnCl2, and Brij-35.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

60 kDa, reducing conditions

theoretical molecular weight :

52 kDa

gene symbol :

Adam10

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2 (Catalog # ES003 ). The specific activity is 5 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O35598

applications :

Enzyme Activity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived mouse ADAM10 protein Thr215-Glu673, with a C-terminal 10-His tag

source short :

Sf 21 (baculovirus)

USD :

618 USD

alt names :

a disintegrin and metalloprotease domain 10, a disintegrin and metalloproteinase domain 10, AD10, ADAM 10, ADAM metallopeptidase domain 10, CD156c, CD156c antigen, CDw156, disintegrin and metalloproteinase domain-containing protein 10, EC 3.4.24, HsT18717, kuz, Kuzbanian, Kuzbanian protein homolog, MADM, MADMEC 3.4.24.81, Mammalian disintegrin-metalloprotease

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage