Recombinant Human DR3/TNFRSF25 Fc Chimera Protein, CF | R&D Systems 943-D3-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human DR3/TNFRSF25 Fc Chimera Protein, CF

catalog :

943-D3-050

quantity :

50 ug

price :

443 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Zwolak A, Chan S, Harvilla P, Mahady S, Armstrong A, Luistro L, et al. A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3. Sci Rep. 2022;12:20538 pubmed publisher
Oriol Tordera B, Olvera A, Duran Castells C, Llano A, Mothe B, Massanella M, et al. TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses. J Immunol. 2020;205:3348-3357 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Levin I, Zaretsky M, Aharoni A. Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion. PLoS ONE. 2017;12:e0173460 pubmed publisher
Hedl M, Abraham C. A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1. Proc Natl Acad Sci U S A. 2014;111:13451-6 pubmed publisher
Liu C, Li X, Gao W, Liu W, Liu D. Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity. PLoS ONE. 2014;9:e92743 pubmed publisher
Krysov S, Rowley T, Al Shamkhani A. Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells. Mol Cancer Ther. 2007;6:703-11 pubmed

product information

brand :

R&D Systems

master code :

943-D3

SKU :

943-D3-050

product name :

Recombinant Human DR3/TNFRSF25 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human DR3/TNFRSF25 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human DR3/TNFRSF25 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

DR3/TNFRSF25

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and EDTA.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

50-65 kDa, reducing conditions

theoretical molecular weight :

46.6 kDa (monomer)

gene symbol :

TNFRSF25

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human TL1A/TNFSF15 (Catalog # 1319-TL/CF) is immobilized at 2 ╡g/mL (100 ╡L/well), Recombinant Human DR3/TNFRSF25 Fc Chimera binds with an ED50 of 0.185-2.40 ╡g/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q93038.2

applications :

Binding Activity

source :

NS0-derived Recombinant Human DR3/TNFRSF25 Fc Chimera Protein, CF

USD :

443 USD

alt names :

Apo-3, APO3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, DR3member 12 (translocatingchain-association membrane protein), LARD, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, TNFRSF25, TRAMP, tumor necrosis factor receptor superfamily, member 25, WSL, WSL1, WSL-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage