Recombinant Human ADAM9 Protein, CF | R&D Systems 939-AD-020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAM9 Protein, CF

catalog :

939-AD-020

quantity :

20 ug

price :

480 USD

citations: 10

Reference
Scribner J, Hicks S, Sinkevicius K, Yoder N, Diedrich G, Brown J, et al. Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors. Mol Cancer Ther. 2022;21:1047-1059 pubmed publisher
Le T, Hsieh C, Lin I, Chu C, Do A, Chen S, et al. The ADAM9/UBN2/AKR1C3 axis promotes resistance to androgen-deprivation in prostate cancer. Am J Cancer Res. 2022;12:176-197 pubmed
Goto K, Arai J, Stephanou A, Kato N. Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10. Oncotarget. 2018;9:18821-18831 pubmed publisher
Giebeler N, Schönefuß A, Landsberg J, Tuting T, Mauch C, Zigrino P. Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis. Oncogene. 2017;36:5058-5067 pubmed publisher
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia A, et al. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015;6:6175 pubmed publisher
Roychaudhuri R, Hergrueter A, Polverino F, Laucho Contreras M, Gupta K, Borregaard N, et al. ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury. J Immunol. 2014;193:2469-82 pubmed publisher
Moss M, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart P, et al. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem. 2007;282:35712-21 pubmed
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed
Karadag A, Zhou M, Croucher P. ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin. Blood. 2006;107:3271-8 pubmed
Hinkle C, Sunnarborg S, Loiselle D, Parker C, Stevenson M, Russell W, et al. Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem. 2004;279:24179-88 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

939-AD

SKU :

939-AD-020

product name :

Recombinant Human ADAM9 Protein, CF

description :

The Recombinant Human ADAM9 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ADAM9 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAM9

unit size :

20 ug

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

observed molecular weight :

64 kDa, reducing conditions

theoretical molecular weight :

55 kDa

gene symbol :

ADAM9

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2 (Catalog # ES003 ). The specific activity is 1.0 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q13443

applications :

Enzyme Activity

product keywords :

939-AD, rhADAM9, hADAM9, carrier-free, carrier free, 939AD, ADAM 9, Metalloproteinase, Metalloprotease

source :

NS0-derived Recombinant Human ADAM9 Protein, CF

USD :

470

USD 2025 :

480 USD

alt names :

a disintegrin and metalloproteinase domain 9 (meltrin gamma), ADAM 9, ADAM metallopeptidase domain 9, ADAM metallopeptidase domain 9 (meltrin gamma), Cellular disintegrin-related protein, cone rod dystrophy 9, CORD9, disintegrin and metalloproteinase domain-containing protein 9, EC 3.4.24, EC 3.4.24.-, MCMP, MCMPMDC9KIAA0021Mltng, MDC9, Meltrin gamma, Meltrin-gamma, Metalloprotease/disintegrin/cysteine-rich protein 9, MLTNG, Myeloma cell metalloproteinase