Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF | R&D Systems 938-VC-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF

catalog :

938-VC-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Gioelli N, Neilson L, Wei N, Villari G, Chen W, Kuhle B, et al. Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability. Nat Commun. 2022;13:4188 pubmed publisher
Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant M, Chrzanowska Wodnicka M. Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. J Cell Sci. 2018;131: pubmed publisher
Zhang P, Feng S, Liu G, Wang H, Zhu H, Ren Q, et al. Mutant B-Raf(V600E) Promotes Melanoma Paracellular Transmigration by Inducing Thrombin-mediated Endothelial Junction Breakdown. J Biol Chem. 2016;291:2087-106 pubmed publisher
Dunne E, Spring C, Reheman A, Jin W, Berndt M, Newman D, et al. Cadherin 6 has a functional role in platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol. 2012;32:1724-31 pubmed publisher
Li X, Edholm D, Lanner F, Breier G, Farnebo F, Dimberg A, et al. Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic stem cells shows early priming of endothelial precursors. Stem Cells. 2007;25:2987-95 pubmed

product information

brand :

R&D Systems

master code :

938-VC

SKU :

938-VC-050

product name :

Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF from R&D Systems is derived from NS0. The Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF has been validated for the following applications: Bioactivity.

target :

VE-Cadherin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

116 kDa, reducing conditions

theoretical molecular weight :

89 kDa (monomer)

gene symbol :

CDH5

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of BCE C/D-1b bovine corneal endothelial cells. The ED50 for this effect is 40-160 ng/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P33151

applications :

Bioactivity

source :

NS0-derived Recombinant Human VE-Cadherin Fc Chimera His-tag Protein, CF

USD :

432 USD

alt names :

7B4, 7B4 antigen, cadherin 5, type 2 (vascular endothelium), cadherin 5, type 2, VE-cadherin (vascular epithelium), cadherin-5, CD144, CD144 antigen, CDH5, endothelial-specific cadherin, FLJ17376, Vascular endothelial cadherin, VE-cadherin, VECadherin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage