product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human SIRP alpha/CD172a His-tag Protein, CF
catalog :
9378-SA-050
quantity :
50 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Vladimirova Y, M xf8 lmer M, Antonsen K, M xf8 ller N, Rittig N, Nielsen M, et al. A New Serum Macrophage Checkpoint Biomarker for Innate Immunotherapy: Soluble Signal-Regulatory Protein Alpha (sSIRPα). Biomolecules. 2022;12: pubmed publisher
van Bommel P, He Y, Schepel I, Hendriks M, Wiersma V, van Ginkel R, et al. CD20-selective inhibition of CD47-SIRPα "don't eat me" signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab. Oncoimmunology. 2018;7:e1386361 pubmed publisher
product information
brand :
R&D Systems
master code :
9378-SA
SKU :
9378-SA-050
product name :
Recombinant Human SIRP alpha/CD172a His-tag Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human SIRP alpha/CD172a His-tag Protein, CF from R&D Systems is derived from CHO. The Recombinant Human SIRP alpha/CD172a His-tag Protein, CF has been validated for the following applications: Bioactivity.
target :
SIRP alpha/CD172a
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
44-63 kDa, reducing conditions
theoretical molecular weight :
38 kDa
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human SIRP alpha /CD172a His-tag is coated at 0.5 ╡g/mL, 100 ╡L/well, Recombinant Human CD47 Fc Chimera (Catalog # 4670-CD ) binds with an ED50 of 0.04-0.24 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human SIRP alpha/CD172a His-tag Protein Bioactivity
accessionNumbers :
NP_542970.1
applications :
Bioactivity
source :
CHO-derived Recombinant Human SIRP alpha/CD172a His-tag Protein, CF
USD :
443 USD
alt names :
Bit, BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, CD172a antigen, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MFR, MFRtyrosine phosphatase SHP substrate 1, MYD1, MYD-1, MyD-1 antigen, P84, protein tyrosine phosphatase, non-receptor type substrate 1, PTPNS1, SHP substrate 1, SHPS1, SHPS-1, SHPS1CD172A, signal-regulatory protein alpha, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRPA, SIRPalpha, SIRP-ALPHA-1, Sirp-alpha-2, SIRPalpha2, Sirp-alpha-3, SIRPtyrosine-protein phosphatase non-receptor type substrate 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.