Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF | R&D Systems 937-4B-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF

catalog :

937-4B-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Au K, Park S, Wang A. Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy. Sci Adv. 2020;6:eaba8564 pubmed publisher
Compte M, Harwood S, Muñoz I, Navarro R, Zonca M, Perez Chacon G, et al. A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Nat Commun. 2018;9:4809 pubmed publisher
Kang Y, Kim S, Shimada S, Otsuka M, Seit Nebi A, Kwon B, et al. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat Immunol. 2007;8:601-9 pubmed

product information

brand :

R&D Systems

master code :

937-4B

SKU :

937-4B-050

product name :

Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity, Binding Activity.

target :

4-1BB/TNFRSF9/CD137

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity, Binding Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

62-66 kDa, reducing conditions

theoretical molecular weight :

44.3 kDa (monomer)

gene symbol :

Tnfrsf9

details of functionality :

Measured by its ability to block 4-1BBL-induced IL-2 secretion by mouse Tácells. The ED50 for this effect is 0.3-1 ╡g/mL in the presence of 0.4 ╡g/mL of recombinant mouse 4-1BBL. Measured by its ability to bind recombinant mouse 4-1BB Ligand in a functional ELISA.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P20334

applications :

Bioactivity, Binding Activity

source :

NS0-derived Recombinant Mouse 4-1BB/TNFRSF9 Fc Chimera Protein, CF

USD :

432 USD

alt names :

41BB, 4-1BB, 4-1BB ligand receptor, CD137, CD137 antigen, CD137MGC2172, CDw137, FLJ43501, ILA, ILAhomolog of mouse 4-1BB, induced by lymphocyte activation (ILA), interleukin-activated receptor, homolog of mouse Ly63, receptor protein 4-1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, tumor necrosis factor receptor superfamily member 9, tumor necrosis factor receptor superfamily, member 9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage