product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human ADAM10 Protein, CF
catalog :
936-AD-020
quantity :
20 ug
price :
618 USD
more info or order :
R&D Systems product webpage
citations: 24
Reference
Segura J, Ireland J, Zou Z, Roth G, Buchwald J, Shen T, et al. HIV-1 release requires Nef-induced caspase activation. PLoS ONE. 2023;18:e0281087 pubmed publisher
Zatovicova M, Kajanová I, Takacova M, Jelenska L, Sedlakova O, Labudova M, et al. ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17. Oncol Rep. 2023;49: pubmed publisher
Skokowa J, Hernandez Alvarez B, Coles M, Ritter M, Nasri M, Haaf J, et al. A topological refactoring design strategy yields highly stable granulopoietic proteins. Nat Commun. 2022;13:2948 pubmed publisher
Yang Y, Tapias V, Acosta D, Xu H, Chen H, Bhawal R, et al. Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nat Commun. 2022;13:159 pubmed publisher
Renfeng Q, Shuxiao C, Peixian G, Kun L, Xuedong F, Hai Y, et al. ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model. Mol Med Rep. 2021;24: pubmed publisher
Carreca A, Pravata V, Markham M, Bonelli S, Murphy G, Nagase H, et al. TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1. Sci Rep. 2020;10:12067 pubmed publisher
Bertran A, Khomiak D, Konopka A, Rejmak E, Bulska E, Seco J, et al. Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorg Chem. 2020;94:103365 pubmed publisher
Ikeda A, Shahid S, Blumberg B, Suzuki M, Bartlett J. ADAM10 is Expressed by Ameloblasts, Cleaves the RELT TNF Receptor Extracellular Domain and Facilitates Enamel Development. Sci Rep. 2019;9:14086 pubmed publisher
Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, et al. Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. J Clin Invest. 2019;130:2390-2403 pubmed publisher
Yoneyama T, Gorry M, Sobo Vujanovic A, Lin Y, Vujanovic L, Gaither Davis A, et al. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. J Cancer. 2018;9:2559-2570 pubmed publisher
Goto K, Arai J, Stephanou A, Kato N. Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10. Oncotarget. 2018;9:18821-18831 pubmed publisher
Colombo A, Hsia H, Wang M, Kuhn P, Brill M, Canevazzi P, et al. Non-cell-autonomous function of DR6 in Schwann cell proliferation. EMBO J. 2018;37: pubmed publisher
Conant K, Daniele S, Bozzelli P, Abdi T, Edwards A, Szklarczyk A, et al. Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation. 2017;14:56 pubmed publisher
Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, et al. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Sci Rep. 2016;6:35598 pubmed publisher
Parra L, Hartmann M, Schubach S, Ma J, Herrlich P, Herrlich A. Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility. Sci Rep. 2016;6:37464 pubmed publisher
Álvarez Fernández S, Barbariga M, Cannizzaro L, Cannistraci C, Hurley L, Zanardi A, et al. Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients. Oncotarget. 2016;7:80059-80076 pubmed publisher
Kløverpris S, Mikkelsen J, Pedersen J, Jepsen M, Laursen L, Petersen S, et al. Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A. J Biol Chem. 2015;290:21915-24 pubmed publisher
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia A, et al. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015;6:6175 pubmed publisher
Lajoie L, Congy Jolivet N, Bolzec A, Gouilleux Gruart V, Sicard E, Sung H, et al. ADAM17-mediated shedding of Fc?RIIIA on human NK cells: identification of the cleavage site and relationship with activation. J Immunol. 2014;192:741-51 pubmed publisher
McDonald A, Dibble J, Evans E, Millhauser G. A new paradigm for enzymatic control of ?-cleavage and ?-cleavage of the prion protein. J Biol Chem. 2014;289:803-13 pubmed publisher
Hayes C, Dey D, Palavicini J, Wang H, Patkar K, Minond D, et al. Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine. BMC Med. 2013;11:81 pubmed publisher
Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, et al. Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res. 2009;69:8050-7 pubmed publisher
Moss M, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart P, et al. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem. 2007;282:35712-21 pubmed
Hinkle C, Sunnarborg S, Loiselle D, Parker C, Stevenson M, Russell W, et al. Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem. 2004;279:24179-88 pubmed
product information
brand :
R&D Systems
master code :
936-AD
SKU :
936-AD-020
product name :
Recombinant Human ADAM10 Protein, CF
unit size :
20 ug
seo description :
The Recombinant Human ADAM10 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human ADAM10 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
ADAM10
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES, NaCl, ZnCl2,Glycerol and Brij-35.
conjugate :
Unconjugated
dilution :
Enzyme Activity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
60 kDa, reducing conditions
theoretical molecular weight :
52 kDa
gene symbol :
ADAM10
details of functionality :
Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 (Catalog # ES010 ). The specific activity is 20 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O14672
applications :
Enzyme Activity
source :
Sf 21 (baculovirus)-derived Recombinant Human ADAM10 Protein, CF
USD :
618 USD
alt names :
a disintegrin and metalloprotease domain 10, a disintegrin and metalloproteinase domain 10, AD10, ADAM 10, ADAM metallopeptidase domain 10, CD156c, CD156c antigen, CDw156, disintegrin and metalloproteinase domain-containing protein 10, EC 3.4.24, HsT18717, kuz, Kuzbanian, Kuzbanian protein homolog, MADM, MADMEC 3.4.24.81, Mammalian disintegrin-metalloprotease
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.