Recombinant Human BACE-1 Protein, CF | R&D Systems 931-AS product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BACE-1 Protein, CF

catalog :

931-AS

quantity :

50 ug

price :

339 USD

citations: 4

Reference
Netzer W, Bettayeb K, Sinha S, Flajolet M, Greengard P, Bustos V. Gleevec shifts APP processing from a Î²-cleavage to a nonamyloidogenic cleavage. Proc Natl Acad Sci U S A. 2017;114:1389-1394 pubmed publisher
Thomas R, Liddell J, Kidd E. Anti-amyloid precursor protein immunoglobulins inhibit amyloid-? production by steric hindrance. FEBS J. 2011;278:167-78 pubmed publisher
Ahmed R, Holler C, Webb R, Li F, Beckett T, Murphy M. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem. 2010;112:1045-53 pubmed publisher
Na C, Jeon S, Zhang G, Olson G, Chae C. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein. J Neurochem. 2007;101:1583-95 pubmed

product information

brand :

R&D Systems

master code :

931-AS

SKU :

931-AS-050

product name :

Recombinant Human BACE-1 Protein, CF

description :

The Recombinant Human BACE-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human BACE-1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

BACE-1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

68-70 kDa and 65-67 kDa, reducing conditions

theoretical molecular weight :

50 kDa (Pro form) 47 kDa (Mature form)

gene symbol :

BACE1

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2 (Catalog # ES004 ). The specific activity is 3.5 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

931-AS

accessionNumbers :

P56817.1

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human BACE-1 protein Thr22-Tyr460 (pro) & Glu46-Tyr460 (mature), both with a C-terminal 10-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

APP beta-secretase, ASP2, Aspartyl protease 2, BACE1, BACEAsp 2, beta-secretase 1, beta-secretase 1 precursor variant 1, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, beta-site APP-cleaving enzyme 1, EC 3.4.23, EC 3.4.23.46, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.