Recombinant Human ACE Protein, CF | R&D Systems 929-ZN-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ACE Protein, CF

catalog :

929-ZN-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Al Mulhim N, Kehoe P, Miners J. Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease. Acta Neuropathol Commun. 2019;7:57 pubmed publisher
South A, Nixon P, Chappell M, Diz D, Russell G, Shaltout H, et al. Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm. J Pediatr. 2019;205:55-60.e1 pubmed publisher
Fagyas M, Ãšri K, Siket I, FÃ¼lÃ¶p G, CsatÃ³ V, DaragÃ³ A, et al. New perspectives in the renin-angiotensin-aldosterone system (RAAS) II: albumin suppresses angiotensin converting enzyme (ACE) activity in human. PLoS ONE. 2014;9:e87844 pubmed publisher
Roosterman D, Kempkes C, Cottrell G, Padilla B, Bunnett N, Turck C, et al. Endothelin-converting enzyme-1 degrades internalized somatostatin-14. Endocrinology. 2008;149:2200-7 pubmed publisher
Miners J, Verbeek M, Rikkert M, Kehoe P, Love S. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J Neurosci Methods. 2008;167:229-36 pubmed
de Lang A, Osterhaus A, Haagmans B. Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells. Virology. 2006;353:474-81 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

929-ZN

SKU :

929-ZN-010

product name :

Recombinant Human ACE Protein, CF

Description :

The Recombinant Human ACE Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ACE Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ACE/CD143

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, NaCl, ZnCl2 and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

160-180 kDa, under reducing conditions.

theoretical molecular weight :

143 kDa

gene symbol :

ACE

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (Catalog # ES005 ). The specific activity is 1,000 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P12821.1

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human ACE Protein

USD :

423 USD

alt names :

ACE1angiotensin converting enzyme, somatic isoform, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, DCP, DCP1, DCP1angiotensin-converting enzyme, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, EC 3.2.1.-, EC 3.4.15.1, Kininase II, MGC26566, MVCD3, peptidase P, testicular ECA

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage