product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human GDF-15 (E. coli-expressed) Protein, CF
catalog :
9279-GD-050
quantity :
50 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Feetham C, Collabolletta V, Worth A, Shoop R, Groom S, Harding C, et al. Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling. Nat Commun. 2024;15:10749 pubmed publisher
L xf6 sch L, Stemmler A, Fischer A, Steinmetz J, Schuldt L, Hennig C, et al. GDF15 Promotes the Osteogenic Cell Fate of Periodontal Ligament Fibroblasts, thus Affecting Their Mechanobiological Response. Int J Mol Sci. 2023;24: pubmed publisher
Wang S, Chang Y, Fang W, Li A, Chen C, Yeh T, et al. Growth differentiation factor 15 induces cisplatin resistance through upregulation of xCT expression and glutathione synthesis in gastric cancer. Cancer Sci. 2023;: pubmed publisher
Peng N, Kang H, Feng Y, Minikes A, Jiang X. Autophagy inhibition signals through senescence to promote tumor suppression. Autophagy. 2022;:1-17 pubmed publisher
Maschalidi S, Mehrotra P, Ke xe7 eli B, De Cleene H, Lecomte K, Van der Cruyssen R, et al. Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes. Nature. 2022;606:776-784 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
9279-GD
SKU :
9279-GD-050
product name :
Recombinant Human GDF-15 (E. coli-expressed) Protein, CF
units size :
50 ug
description :
The Recombinant Human GDF-15 (E. coli-expressed) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human GDF-15 (E. coli-expressed) Protein, CF has been validated for the following applications: Bioactivity.
target :
GDF-15
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in HCl.
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
12 kDa, reducing conditions
theoretical molecular weight :
12 kDa
details of functionality :
Measured by its binding ability in a functional ELISA. Recombinant Human GDF-15 (Catalog # 9279-GD) binds to Recombinant Human GFR alpha -like Fc Chimera (Catalog # 9697-GR ) with an ED50 of 0.0500-0.500 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q99988
applications :
Bioactivity
source :
E. coli-derived Recombinant Human GDF-15 (E. coli-expressed) Protein, CF
USD :
400 USD
alt names :
GDF15, growth differentiation factor 15, growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC-1, MIC-1NSAID-activated gene 1 protein, MIC1Prostate differentiation factor, NAG-1, NAG-1NSAID-regulated gene 1 protein, NSAID (nonsteroidal inflammatory drug)-activated protein 1, PDF, PDFGDF-15, PLAB, PLABNRG-1, Placental bone morphogenetic protein, Placental TGF-beta, PTGF-beta, PTGFBPTGF-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.