product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Proprotein Convertase 9/PCSK9 Protein, CF
catalog :
9258-SE-020
quantity :
20 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Fowler A, Van Rompay K, Sampson M, Leo J, Watanabe J, Usachenko J, et al. A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates. bioRxiv. 2023;: pubmed publisher
Pakalni x161 kyt x117 D, Sch xf6 nberger T, Strobel B, Stierstorfer B, Lamla T, Schuler M, et al. Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery. Sci Rep. 2022;12:19268 pubmed publisher
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song C, et al. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Mol Cell. 2019;73:714-726.e4 pubmed publisher
Ibraheim R, Song C, Mir A, Amrani N, Xue W, Sontheimer E. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018;19:137 pubmed publisher
product information
master code :
9258-SE
SKU :
9258-SE-020
product name :
Recombinant Mouse Proprotein Convertase 9/PCSK9 Protein, CF
unit size :
20 ug
description :
The Recombinant Mouse Proprotein Convertase 9/PCSK9 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Proprotein Convertase 9/PCSK9 Protein, CF has been validated for the following applications: Bioactivity.
target :
Proprotein Convertase 9/PCSK9
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in Tris, NaCl and Glycerol.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
18 kDa (pro domain) and 57-67 kDa (mature form), reducing conditions
theoretical molecular weight :
14 kDa (pro domain) and 59 kDa (mature form)
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Mouse LDLR (Catalog # 2255-LD) is coated at 2 ╡g/mL, Recombinant Mouse Proprotein Convertase 9/PCSK9 (Catalog # 9258-SE) binds with an ED50 = 25-150 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse Proprotein Convertase 9/PCSK9 Protein Bioactivity
accessionNumbers :
Q80W65
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived mouse Proprotein Convertase 9/PCSK9 protein Ser156-Gln694 with a C-terminal 10-His tag; Gln35-Gln155
source short :
NS0
USD :
432 USD
alt names :
EC 3.4.21, EC 3.4.21.111, FH3, FH3neural apoptosis regulated convertase 1, FHCL3, HCHOLA3, hypercholesterolemia, autosomal dominant 3, LDLCQ1, NARC1, NARC-1, NARC-1convertase subtilisin/kexin type 9 preproprotein, NARC1EC 3.4.21.-, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.