Recombinant Mouse/Rat MMP-2 Protein, CF | R&D Systems 924-MP-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse/Rat MMP-2 Protein, CF

catalog :

924-MP-010

quantity :

10 ug

price :

438 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Szóstek Mioduchowska A, Słowińska M, Pacewicz J, Skarzynski D, Okuda K. Matrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis. Sci Rep. 2020;10:1119 pubmed publisher
Mirastschijski U, Lupse B, Maedler K, Sarma B, Radtke A, Belge G, et al. Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin. Int J Mol Sci. 2019;20: pubmed publisher
Eshaq R, Harris N. Loss of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) in the Diabetic Retina: Role of Matrix Metalloproteinases. Invest Ophthalmol Vis Sci. 2019;60:748-760 pubmed publisher
D Onofrio P, Shabanzadeh A, Choi B, Bahr M, Koeberle P. MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage. Invest Ophthalmol Vis Sci. 2019;60:634-649 pubmed publisher
Kim H, Vargas A, Eom Y, Li J, Yamamoto K, CRAFT C, et al. Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina. PLoS ONE. 2018;13:e0197322 pubmed publisher
Rempe R, Hartz A, Soldner E, Sokola B, Alluri S, Abner E, et al. Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy. J Neurosci. 2018;38:4301-4315 pubmed publisher
Shin J, Kim H, Vargas A, Yu W, Eom Y, CRAFT C, et al. Inhibition of Matrix Metalloproteinase 9 Enhances Rod Survival in the S334ter-line3 Retinitis Pigmentosa Model. PLoS ONE. 2016;11:e0167102 pubmed publisher
Carvalho P, Gonçalves A, Alegre P, Azevedo P, Roscani M, Bergamasco C, et al. Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats. Cell Physiol Biochem. 2016;40:431-442 pubmed
Sottnik J, Dai J, Zhang H, Campbell B, Keller E. Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Cancer Res. 2015;75:2151-8 pubmed publisher
Burston J, Sagar D, Shao P, Bai M, King E, Brailsford L, et al. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. PLoS ONE. 2013;8:e80440 pubmed publisher
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190:5329-36 pubmed publisher
Song J, Wu C, Zhang X, Sorokin L. In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1?-induced peritonitis. J Immunol. 2013;190:401-10 pubmed publisher
Suryawanshi A, Mulik S, Sharma S, Reddy P, Sehrawat S, Rouse B. Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor. J Immunol. 2011;186:3653-65 pubmed publisher
Le Quement C, Guenon I, Gillon J, Valenca S, Cayron Elizondo V, Lagente V, et al. The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke. Br J Pharmacol. 2008;154:1206-15 pubmed publisher
Rafei M, Wu J, Annabi B, Lejeune L, Francois M, Galipeau J. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood. 2007;109:2234-42 pubmed
Bruno M, Cuello A. Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. Proc Natl Acad Sci U S A. 2006;103:6735-40 pubmed

product information

brand :

R&D Systems

master code :

924-MP

SKU :

924-MP-010

product name :

Recombinant Mouse/Rat MMP-2 Protein, CF

description :

The Recombinant Mouse/Rat MMP-2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse/Rat MMP-2 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

MMP-2

category :

Proteins and Enzymes

sizes available :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, CaCl2, NaCl, Brij-35 and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse, Rat

observed molecular weight :

72 kDa, under reducing conditions

theoretical molecular weight :

71 kDa

gene symbol :

Mmp2

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 1,500 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P33434

applications :

Enzyme Activity

source :

NS0-derived Recombinant Mouse/Rat MMP-2 Protein, CF

USD :

431

USD 2023 :

438 USD

alt names :

72 kDa gelatinase, CLG4, CLG4A72 kDa type IV collagenase, collagenase type IV-A, EC 3.4.24, EC 3.4.24.24, Gelatinase A, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase), matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase), Matrix metalloproteinase-2, matrix metalloproteinase-II, MMP2, MMP-2, MMP-II, MONA, neutrophil gelatinase, TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage