product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human VEGF-C Protein
catalog :
9199-VC-025
quantity :
25 ug
price :
396 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
K C R, Patel N, Shenoy A, Scallan J, Chiang M, Galazo M, et al. Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function. bioRxiv. 2023;: pubmed publisher
Farahani P, Yang X, Mesev E, Fomby K, Brumbaugh Reed E, Bashor C, et al. pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. elife. 2023;12: pubmed publisher
Islam R, Mishra J, Polavaram N, Bhattacharya S, Hong Z, Bodas S, et al. Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance. Cell Rep. 2022;40:111097 pubmed publisher
Morfoisse F, De Toni F, Nigri J, Hosseini M, Zamora A, Tatin F, et al. Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis. Cancers (Basel). 2021;13: pubmed publisher
Geng X, Yanagida K, Akwii R, Choi D, Chen L, Ho Y, et al. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020;5: pubmed publisher
Chung T, Kim E, Choi H, Han C, Jang S, Kim K, et al. 6'-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis. Exp Mol Med. 2019;51:1-13 pubmed publisher
López Bellido R, Puig S, Huang P, Tsai C, Turner H, Galko M, et al. Growth factor signaling regulates mechanical nociception in flies and vertebrates. J Neurosci. 2019;: pubmed publisher
Frye M, Taddei A, Dierkes C, Martínez Corral I, Fielden M, Ortsäter H, et al. Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nat Commun. 2018;9:1511 pubmed publisher
Lin Y, Ohbayashi N, Hongu T, Katagiri N, Funakoshi Y, Lee H, et al. Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration. Sci Rep. 2017;7:11431 pubmed publisher
Campbell K, Hadley D, Kukis D, Silva E. Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications. PLoS ONE. 2017;12:e0181484 pubmed publisher
Yu S, Lv H, Zhang H, Jiang Y, Hong Y, Xia R, et al. Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway. Biochem Biophys Res Commun. 2017;485:432-439 pubmed publisher
image
image 1 :
R&D Systems 9199-VC-025 image 1
Recombinant Human VEGF-C Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
9199-VC
SKU :
9199-VC-025
product name :
Recombinant Human VEGF-C Protein
Description :
The Recombinant Human VEGF-C Protein from R&D Systems is derived from CHO. The Recombinant Human VEGF-C Protein has been validated for the following applications: Bioactivity.
target :
VEGF-C
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in HCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
14-22 kDa, reducing conditions
theoretical molecular weight :
13 kDa
details of functionality :
Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells. Marconcini, L. et al . (1999) Proc. Natl. Acad. Sci. USA 96 :9671. The ED50 for this effect is 1.5-9 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P49767
applications :
Bioactivity
source :
CHO-derived Recombinant Human VEGF-C Protein
USD :
396 USD
alt names :
Flt4 ligand, Flt4-L, vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, VEGFC, VEGF-C, VRPFLT4 ligand DHM
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.