Recombinant Human CTGF/CCN2 Protein, CF | R&D Systems 9190-CC-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CTGF/CCN2 Protein, CF

catalog :

9190-CC-050

quantity :

50 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Wang Y, Liu X, Xu Q, Xu W, Zhou X, Lin Z. CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development. JCI Insight. 2023;8: pubmed publisher
Nakayama T, Azegami T, Hayashi K, Hishikawa A, Yoshimoto N, Nakamichi R, et al. Vaccination against connective tissue growth factor attenuates the development of renal fibrosis. Sci Rep. 2022;12:10933 pubmed publisher
He C, Jiang B, Wang M, Ren P, Murtada S, Caulk A, et al. mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI Insight. 2022;7: pubmed publisher
Soundararajan A, Ghag S, Vuda S, Wang T, Pattabiraman P. Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway. Cells. 2021;10: pubmed publisher
Simoni L, Presumey J, van der Poel C, Castrillón C, Chang S, Utz P, et al. Complement C4A Regulates Autoreactive B Cells in Murine Lupus. Cell Rep. 2020;33:108330 pubmed publisher
Hellinger J, Schömel F, Buse J, Lenz C, Bauerschmitz G, Emons G, et al. Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling. Sci Rep. 2020;10:17889 pubmed publisher
Muraguchi T, Nanba D, Nishimura E, Tashiro T. IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance. J Dermatol Sci. 2019;: pubmed publisher
Mann A, Scodeller P, Hussain S, Braun G, Mölder T, Toome K, et al. Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun. 2017;8:1403 pubmed publisher

product information

master code :

9190-CC

SKU :

9190-CC-050

product name :

Recombinant Human CTGF/CCN2 Protein, CF

unit size :

50 ug

description :

The Recombinant Human CTGF/CCN2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human CTGF/CCN2 Protein, CF has been validated for the following applications: Bioactivity.

target :

CTGF/CCN2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

35-45 kDa, reducing conditions

theoretical molecular weight :

35 kDa

details of functionality :

Measured by its ability to mediate Balb/3T3 mouse embryonic fibroblast cell adhesion. Ball, D.K. etáal . (2003) Reproduction 125 :271. The ED50 for this effect is1.5-7.5 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human CTGF/CCN2 Protein Bioactivity

accessionNumbers :

Q5M8T4

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human CTGF/CCN2 protein Gln27-Ala349

source short :

NS0

USD :

400 USD

alt names :

CCN2, CCN2IGFBP-8, connective tissue growth factor, CTGRP, Fisp12, HCS24, Hypertrophic chondrocyte-specific protein 24, IBP-8, IGF-binding protein 8, IGFBP-8, IGFBP8CCN family member 2, Insulin-like growth factor-binding protein 8, MGC102839, NOV2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage