Recombinant Human MMP-14/MT1-MMP Protein, CF | R&D Systems 918-MP-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MMP-14/MT1-MMP Protein, CF

catalog :

918-MP-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Knapinska A, Drotleff G, Chai C, Twohill D, Ernce A, Tokmina Roszyk D, et al. Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids. Biomedicines. 2023;11: pubmed publisher
Daquinag A, Gao Z, Fussell C, Sun K, Kolonin M. Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly. Cells. 2020;9: pubmed publisher
Falkowski K, Bielecka E, Thøgersen I, Bocheńska O, Płaza K, Kalińska M, et al. Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis. Int J Mol Sci. 2020;21: pubmed publisher
Devel L, Almer G, Cabella C, Beau F, Bernes M, Oliva P, et al. Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model. Molecules. 2019;24: pubmed publisher
Swayampakula M, McDonald P, Vallejo M, Coyaud E, Chafe S, Westerback A, et al. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Oncogene. 2017;36:6244-6261 pubmed publisher
Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia A, et al. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015;6:6175 pubmed publisher
Birukawa N, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, et al. Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth. J Biol Chem. 2014;289:20209-21 pubmed publisher
Haage A, Schneider I. Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells. FASEB J. 2014;28:3589-99 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher
Tsuchiya S, Simmer J, Hu J, Richardson A, Yamakoshi F, Yamakoshi Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). J Bone Miner Res. 2011;26:220-8 pubmed publisher
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

918-MP

SKU :

918-MP-010

product name :

Recombinant Human MMP-14/MT1-MMP Protein, CF

Description :

The Recombinant Human MMP-14/MT1-MMP Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human MMP-14/MT1-MMP Protein, CF has been validated for the following applications: Enzyme Activity.

target :

MMP-14/MT1-MMP

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, NaCl, CaCl2 and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

31 kDa, reducing conditions

theoretical molecular weight :

31 kDa

gene symbol :

MMP14

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 (Catalog # ES010 ). The specific activity is 450 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P50281

applications :

Enzyme Activity

source :

E. coli-derived Recombinant Human MMP-14/MT1-MMP Protein

USD :

423 USD

alt names :

EC 3.4.24, EC 3.4.24.80, matrix metallopeptidase 14 (membrane-inserted), matrix metalloproteinase 14 (membrane-inserted), matrix metalloproteinase-14, membrane type 1 metalloprotease, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, MMP14, MMP-14, MMP-X1, MT1MMP, MT1-MMP, MT1-MMPMTMMP1, MT-MMP 1, MT-MMP1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage