Recombinant Human MMP-12 Protein, CF | R&D Systems 917-MPB product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MMP-12 Protein, CF

catalog :

917-MPB

quantity :

20 ug

price :

339 USD

citations: 9

Reference
Aristorena M, Gallardo Vara E, Vicen M, de Las Casas Engel M, Ojeda Fernandez L, Nieto C, et al. MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Ye Y, Toczek J, Gona K, Kim H, Han J, Razavian M, et al. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Sci Rep. 2018;8:11647 pubmed publisher
Kondo N, Temma T, Aita K, Shimochi S, Koshino K, Senda M, et al. Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography. Sci Rep. 2018;8:1347 pubmed publisher
King S, Joshi H, Schjoldager K, Halim A, Madsen T, Dziegiel M, et al. Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells. Blood Adv. 2017;1:429-442 pubmed publisher
Kristensen J, Karsdal M, Sand J, Willumsen N, Diefenbach C, Svensson B, et al. Serological assessment of neutrophil elastase activity on elastin during lung ECM remodeling. BMC Pulm Med. 2015;15:53 pubmed publisher
Sand J, Larsen L, Hogaboam C, Martinez F, Han M, Røssel Larsen M, et al. MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays. PLoS ONE. 2013;8:e84934 pubmed publisher
Djokic J, Fagotto Kaufmann C, Bartels R, Nelea V, Reinhardt D. Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers. J Biol Chem. 2013;288:22821-35 pubmed publisher
Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed

product information

brand :

R&D Systems

master code :

917-MPB

SKU :

917-MPB-020

product name :

Recombinant Human MMP-12 Protein, CF

description :

The Recombinant Human MMP-12 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MMP-12 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

MMP-12

category :

Proteins and Enzymes

unit size :

20 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES, NaCl, CaCl2, CHAPS, ZnSO4 and PEG.

conjugate :

Unconjugated

main entrez gene id :

4321

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

53-60 kDa, reducing conditions

theoretical molecular weight :

52 kDa

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 500 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

917-MPB

accessionNumbers :

P39900

applications :

Enzyme Activity

source :

The Recombinant Human MMP-12 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MMP-12 Protein, CF has been validated for the following applications: Enzyme Activity.

USD :

339 USD

alt names :

EC 3.4.24, hME, HMEEC 3.4.24.65, Macrophage elastase, macrophage metalloelastase, matrix metallopeptidase 12 (macrophage elastase), matrix metalloproteinase 12 (macrophage elastase), Matrix metalloproteinase-12, ME, MGC138506, MME, MMP12, MMP-12

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.