product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Neutrophil Elastase/ELA2 Protein, CF
catalog :
9167-SE-020
quantity :
20 ug
price :
428 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Cheung P, Schaffert S, Chang S, Dvorak M, Donato M, Macaubas C, et al. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Nat Immunol. 2021;22:711-722 pubmed publisher
Li Z, Peirasmaki D, Svärd S, Abrink M. The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardiaintestinalis. Cells. 2020;9: pubmed publisher
Guo J, Tu J, Hu Y, Song G, Yin Z. Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis. Drug Des Devel Ther. 2019;13:581-588 pubmed publisher
product information
brand :
R&D Systems
master code :
9167-SE
SKU :
9167-SE-020
product name :
Recombinant Human Neutrophil Elastase/ELA2 Protein, CF
description :
The Recombinant Human Neutrophil Elastase/ELA2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Neutrophil Elastase/ELA2 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Neutrophil Elastase/ELA2
category :
Proteins and Enzymes
sizes available :
20 ug
buffer :
Supplied as a 0.2 µm filtered solution in HEPES and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
29-39 kDa, reducing conditions
theoretical molecular weight :
25 kDa
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, MeOSuc-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin (MeOSuc-AAPV-AMC). The specific activity is 1,500 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P08246
applications :
Enzyme Activity
source :
CHO-derived Recombinant Human Neutrophil Elastase/ELA2 Protein, CF
USD :
421
USD 2023 :
428 USD
alt names :
Bone marrow serine protease, EC 3.4.21, EC 3.4.21.37, ELA2, ELA2granulocyte-derived elastase, ELANE, elastase 2, neutrophil, elastase, neutrophil expressed, Elastase-2, GE, HLEelastase-2, HNE, Human leukocyte elastase, Leukocyte Elastase, medullasin, NE, neutrophil elastase, PMN elastase, PMN-E, polymorphonuclear elastase, SCN1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.