Recombinant Human IFN-lambda 4 Protein, CF | R&D Systems 9165-IF-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IFN-lambda 4 Protein, CF

catalog :

9165-IF-025

quantity :

25 ug

price :

601 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
De M, Bhushan A, Grubbe W, Roy S, Mendoza J, Chinnaswamy S. Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages. Genes Immun. 2022;23:73-84 pubmed publisher
Lunova M, Kubovčiak J, Smolková B, Uzhytchak M, Michalova K, Dejneka A, et al. Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling. Int J Mol Sci. 2021;22: pubmed publisher
De M, Bhushan A, Chinnaswamy S. Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes. J Leukoc Biol. 2020;: pubmed publisher
Chung J, Hong S, Seo N, Kim T, An H, Lee P, et al. Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency. Cytokine. 2020;125:154833 pubmed publisher
Caine E, Scheaffer S, Arora N, Zaitsev K, Artyomov M, Coyne C, et al. Interferon lambda protects the female reproductive tract against Zika virus infection. Nat Commun. 2019;10:280 pubmed publisher
Obajemu A, Rao N, Dilley K, Vargas J, Sheikh F, Donnelly R, et al. IFN-Î»4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling. J Immunol. 2017;199:3808-3820 pubmed publisher

image

image 1 :

Recombinant Human IFN-lambda 4 Protein Bioactivity

product information

brand :

R&D Systems

master code :

9165-IF

SKU :

9165-IF-025

product name :

Recombinant Human IFN-lambda 4 Protein, CF

description :

The Recombinant Human IFN-lambda 4 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IFN-lambda 4 Protein, CF has been validated for the following applications: Bioactivity.

target :

IFN-lambda 4

category :

Proteins and Enzymes

sizes available :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Citric Acid and CHAPS.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

19 kDa, reducing conditions

theoretical molecular weight :

18 kDa

details of functionality :

Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 0.2-1.2 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

K9M1U5

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IFN-lambda 4 Protein, CF

USD :

572

USD 2023 :

601 USD

alt names :

IFNAN, IFNL4, IFNlambda 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage