product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-18/IL-1F4 Protein
catalog :
9139-IL-050
quantity :
50 ug (also 10 ug, 500 ug)
price :
362 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Tougaard P, Ruiz P xe9 rez M, Steels W, Huysentruyt J, Verstraeten B, Vetters J, et al. Type 1 immunity enables neonatal thymic ILC1 production. Sci Adv. 2024;10:eadh5520 pubmed publisher
LaMarche N, Hegde S, Park M, Maier B, Troncoso L, Le Bérichel J, et al. An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024;625:166-174 pubmed publisher
Schafer C, Martin Almedina S, Kurylowicz K, Dufton N, Osuna Almagro L, Wu M, et al. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge. bioRxiv. 2023;: pubmed publisher
Zhao X, Peng T, Cao X, Hou Y, Li R, Han T, et al. In vivo G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-γ secretion by natural killer cells. Cell Rep. 2022;40:111342 pubmed publisher
Chiang H, Lu H, Sudhakar J, Chen Y, Shih N, Weng Y, et al. IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence. Nat Commun. 2022;13:874 pubmed publisher
Zhao G, Zhang H, Zhu S, Wang S, Zhu K, Zhao Y, et al. Interleukin-18 accelerates cardiac inflammation and dysfunction during ischemia/reperfusion injury by transcriptional activation of CXCL16. Cell Signal. 2021;87:110141 pubmed publisher
Rudak P, Choi J, Parkins K, Summers K, Jackson D, Foster P, et al. Chronic stress physically spares but functionally impairs innate-like invariant T cells. Cell Rep. 2021;35:108979 pubmed publisher
Moral J, Leung J, Rojas L, Ruan J, Zhao J, Sethna Z, et al. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Nature. 2020;579:130-135 pubmed publisher
Ge C, Monk I, Pizzolla A, Wang N, Bedford J, Stinear T, et al. Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment. Cell Rep. 2019;29:4236-4244.e3 pubmed publisher
Jensen I, Winborn C, Fosdick M, Shao P, Tremblay M, Shan Q, et al. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog. 2018;14:e1007405 pubmed publisher
Staudacher J, Yazici C, Carroll T, Bauer J, Pang J, Krett N, et al. Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. Sci Rep. 2017;7:12786 pubmed publisher
product information
master code :
9139-IL
SKU :
9139-IL-050
product name :
Recombinant Mouse IL-18/IL-1F4 Protein
unit size :
50 ug (also 10 ug, 500 ug)
description :
The Recombinant Mouse IL-18/IL-1F4 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-18/IL-1F4 Protein has been validated for the following applications: Bioactivity.
target :
IL-18/IL-1F4
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS, EDTA and DTT with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
17 kDa, reducing conditions
theoretical molecular weight :
18 kDa
details of functionality :
Measured by its ability to induce mouse IFN-gamma secretion by activated mouse T cells. The ED50 for this effect is 0.06-0.36 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse IL-18/IL-1F4 Protein Bioactivity
accessionNumbers :
P70380
applications :
Bioactivity
source long :
E. coli -derived mouse IL-18/IL-1F4 protein Asn36-Ser192
source short :
E. coli
USD :
362 USD
alt names :
Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.