product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-18/IL-1F4 Protein, CF
catalog :
9124-IL-050/CF
quantity :
50 ug (also 10 ug, 500 ug)
price :
362 USD
more info or order :
R&D Systems product webpage
citations: 20
Reference
Parween F, Singh S, Zhang H, Kathuria N, Otaizo Carrasquero F, Shamsaddini A, et al. Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells. bioRxiv. 2023;: pubmed publisher
Zhang X, Luo S, Wang M, Cao Q, Zhang Z, Huang Q, et al. Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation. Nat Commun. 2022;13:7582 pubmed publisher
Zhao X, Peng T, Cao X, Hou Y, Li R, Han T, et al. In vivo G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-γ secretion by natural killer cells. Cell Rep. 2022;40:111342 pubmed publisher
Michaels Y, Edgar J, Major M, Castle E, Zimmerman C, Yin T, et al. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells. Sci Adv. 2022;8:eabn5522 pubmed publisher
Du Y, Khera T, Strunz B, Deterding K, Todt D, Woller N, et al. Imprint of unconventional T-cell response in acute hepatitis C persists despite successful early antiviral treatment. Eur J Immunol. 2022;52:472-483 pubmed publisher
Deschler S, Kager J, Erber J, Fricke L, Koyumdzhieva P, Georgieva A, et al. Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients. Viruses. 2021;13: pubmed publisher
Billiet L, Goetgeluk G, Bonte S, De Munter S, De Cock L, Pille M, et al. Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a- CD95+ CD28- CCR7- Developmental Stage. Int J Mol Sci. 2020;21: pubmed publisher
Zhou B, Wang D, Qiu Y, Airhart S, Liu Y, Stempien Otero A, et al. Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure. J Clin Invest. 2020;130:6054-6063 pubmed publisher
Choi J, Park J, Tsagkogeorga G, Yanagita M, Koo B, Han N, et al. Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration. Cell Stem Cell. 2020;27:366-382.e7 pubmed publisher
Zhu H, Blum R, Bernareggi D, Ask E, Wu Z, Hoel H, et al. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020;27:224-237.e6 pubmed publisher
Sattler A, Thiel L, Ruhm A, Souidi N, Seifert M, Herberth G, et al. The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells. J Immunol. 2019;203:2970-2978 pubmed publisher
Sundström P, Szeponik L, Ahlmanner F, Sundquist M, Wong J, Lindskog E, et al. Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules. Oncotarget. 2019;10:2810-2823 pubmed publisher
Yu J, Lin G, Field J, Linden J. Induction of antiinflammatory purinergic signaling in activated human iNKT cells. JCI Insight. 2018;3: pubmed publisher
Golden Mason L, McMahan R, Kriss M, Kilgore A, Cheng L, Dran R, et al. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018;2:364-375 pubmed publisher
Zimmer C, Rinker F, Höner zu Siederdissen C, Manns M, Wedemeyer H, Cornberg M, et al. Increased NK Cell Function After Cessation of Long-Term Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Is Associated With Liver Damage and HBsAg Loss. J Infect Dis. 2018;217:1656-1666 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Felices M, Lenvik A, McElmurry R, Chu S, Hinderlie P, Bendzick L, et al. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight. 2018;3: pubmed publisher
Jensen H, Chen S, Folkersen L, Nolan G, Lanier L. EBI3 regulates the NK cell response to mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2017;114:1625-1630 pubmed publisher
Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad D, Karunanithi P, et al. Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. J Immunol. 2017;198:1308-1319 pubmed publisher
Vendrame E, Fukuyama J, Strauss Albee D, Holmes S, Blish C. Mass Cytometry Analytical Approaches Reveal Cytokine-Induced Changes in Natural Killer Cells. Cytometry B Clin Cytom. 2017;92:57-67 pubmed publisher
product information
master code :
9124-IL/CF
SKU :
9124-IL-050/CF
product name :
Recombinant Human IL-18/IL-1F4 Protein, CF
unit size :
50 ug (also 10 ug, 500 ug)
description :
The Recombinant Human IL-18/IL-1F4 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-18/IL-1F4 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-18/IL-1F4
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and DTT.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
19 kDa, reducing conditions
theoretical molecular weight :
18 kDa
gene symbol :
IL18
details of functionality :
Measured by its ability to induce IFN-gamma secretion by KG-1 human acute myelogenous leukemia cells in the presence of TNF-alpha . The ED50 for this effect is 1.5-9 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human IL-18/IL-1F4 Protein Bioactivity
accessionNumbers :
Q14116
applications :
Bioactivity
source long :
E. coli -derived human IL-18/IL-1F4 protein Tyr37-Asp193
source short :
E. coli
USD :
362 USD
alt names :
Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.