product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human MMP-8 Protein, CF
catalog :
908-MP-010
quantity :
10 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Ghochani Y, Muthukrishnan S, Sohrabi A, Kawaguchi R, Condro M, Bastola S, et al. A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell Rep. 2022;41:111511 pubmed publisher
Larrouture Q, Cribbs A, Rao S, Philpott M, Snelling S, Knowles H. Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs. Sci Rep. 2021;11:22708 pubmed publisher
Juurikka K, Dufour A, Pehkonen K, Mainoli B, Campioni Rodrigues P, Solis N, et al. MMP8 increases tongue carcinoma cell-cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5. Oncogenesis. 2021;10:44 pubmed publisher
Cassuto J, Folestad A, Göthlin J, Malchau H, Kärrholm J. Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants. Bone Rep. 2020;13:100715 pubmed publisher
Knapinska A, Hart M, Drotleff G, Fields G. Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11. Molecules. 2019;24: pubmed publisher
Elia I, Rossi M, Stegen S, Broekaert D, Doglioni G, Van Gorsel M, et al. Breast cancer cells rely on environmental pyruvate to shape the metastatic niche. Nature. 2019;568:117-121 pubmed publisher
Rottenberger Z, Komorowicz E, Szabó L, Bóta A, Varga Z, Machovich R, et al. Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. J Thromb Haemost. 2013;11:529-38 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher
Tsuchiya S, Simmer J, Hu J, Richardson A, Yamakoshi F, Yamakoshi Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). J Bone Miner Res. 2011;26:220-8 pubmed publisher
Gaggar A, Li Y, Weathington N, Winkler M, Kong M, Jackson P, et al. Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients. Am J Physiol Lung Cell Mol Physiol. 2007;293:L96-L104 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
908-MP
SKU :
908-MP-010
product name :
Recombinant Human MMP-8 Protein, CF
Description :
The Recombinant Human MMP-8 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MMP-8 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
MMP-8
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in Tris, NaCl and CaCl2.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
70 kDa, reducing conditions
theoretical molecular weight :
51 kDa
gene symbol :
MMP8
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 250 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAZ38714
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human MMP-8 Protein
USD :
423 USD
alt names :
CLG1HNC, Collagenase 2, EC 3.4.24, EC 3.4.24.34, matrix metallopeptidase 8 (neutrophil collagenase), matrix metalloproteinase 8 (neutrophil collagenase), Matrix metalloproteinase-8, MMP8, MMP-8, neutrophil collagenase, PMNL collagenase, PMNL-CL
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.