Recombinant Human PD-L1/B7-H1 His-tag Protein, CF | R&D Systems 9049-B7-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PD-L1/B7-H1 His-tag Protein, CF

catalog :

9049-B7-100

quantity :

100 ug

price :

425 USD

citations: 7

Reference
Phetphoung T, Malla A, Rattanapisit K, Pisuttinusart N, Damrongyot N, Joyjamras K, et al. Expression of plant-produced anti-PD-L1 antibody with anoikis sensitizing activity in human lung cancer cells via., suppression on epithelial-mesenchymal transition. PLoS ONE. 2022;17:e0274737 pubmed publisher
Wu Z, Li N, Gao Z, Chen G, Nie L, Zhou Y, et al. Development of the Novel Bifunctional Fusion Protein BR102 That Simultaneously Targets PD-L1 and TGF-β for Anticancer Immunotherapy. Cancers (Basel). 2022;14: pubmed publisher
Le Biannic R, Magnez R, Klupsch F, Leleu Chavain N, Thiroux B, Tardy M, et al. Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction. Eur J Med Chem. 2022;236:114343 pubmed publisher
Sun L, Wang Y, Wang X, Navarro Corcuera A, Ilyas S, Jalan Sakrikar N, et al. PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II. Cell Rep. 2022;38:110349 pubmed publisher
Geuijen C, Tacken P, Wang L, Klooster R, Van Loo P, Zhou J, et al. A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. Nat Commun. 2021;12:4445 pubmed publisher
Park J, Thi E, Carpio V, Bi Y, Cole A, Dorsey B, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021;12:1222 pubmed publisher
Chatterjee S, Lesniak W, Miller M, Lisok A, Sikorska E, Wharram B, et al. Rapid PD-L1 detection in tumors with PET using a highly specific peptide. Biochem Biophys Res Commun. 2017;483:258-263 pubmed publisher

product information

master code :

9049-B7

SKU :

9049-B7-100

product name :

Recombinant Human PD-L1/B7-H1 His-tag Protein, CF

unit size :

100 ug

description :

The Recombinant Human PD-L1/B7-H1 His-tag Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human PD-L1/B7-H1 His-tag Protein, CF has been validated for the following applications: Binding Activity.

target :

PD-L1/B7-H1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

31-41 kDa, reducing conditions

theoretical molecular weight :

26 kDa

gene symbol :

CD274

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human PD-L1/B7-H1 is immobilized at 0.025 ╡g/mL (100 ╡L/well), the concentration of Recombinant Human PD-1 Fc Chimera (Catalog # 1086-PD ) that produces 50% of the optimal binding response is approximately 0.05-0.3 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Graph showing bioactivity of Human PD-L1 protein (B7-H1 protein)

accessionNumbers :

Q9NZQ7

applications :

Binding Activity

source long :

Human embryonic kidney cell, HEK293-derived human PD-L1/B7-H1 protein Phe19-Thr239, with a C-terminal 6-His tag

source short :

HEK293

USD :

425 USD

alt names :

Avelumab, B7-H, B7H1, B7-H1, B7H1PDCD1L1, CD274, CD274 antigenMGC142294, CD274 molecule, PDCD1L1, PDCD1LG1, PDCD1LG1MGC142296, PDL1, PD-L1, PD-L1B7 homolog 1, PDL1PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.