Recombinant Human PD-L1/B7-H1 His-tag Protein, CF | R&D Systems 9049-B7-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PD-L1/B7-H1 His-tag Protein, CF

catalog :

9049-B7-100

quantity :

100 ug

price :

399 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Geuijen C, Tacken P, Wang L, Klooster R, Van Loo P, Zhou J, et al. A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. Nat Commun. 2021;12:4445 pubmed publisher
Park J, Thi E, Carpio V, Bi Y, Cole A, Dorsey B, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021;12:1222 pubmed publisher
Chatterjee S, Lesniak W, Miller M, Lisok A, Sikorska E, Wharram B, et al. Rapid PD-L1 detection in tumors with PET using a highly specific peptide. Biochem Biophys Res Commun. 2017;483:258-263 pubmed publisher

image

image 1 :

Graph showing bioactivity of Human PD-L1 protein (B7-H1 protein)

product information

brand :

R&D Systems

master code :

9049-B7

SKU :

9049-B7-100

product name :

Recombinant Human PD-L1/B7-H1 His-tag Protein, CF

unit size :

100 ug

description :

The Recombinant Human Contactin-1 Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Contactin-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

PD-L1/B7-H1

category :

Proteins and Enzymes

alt names :

Avelumab, B7-H, B7H1, B7-H1, B7H1PDCD1L1, CD274, CD274 antigenMGC142294, CD274 molecule, PDCD1L1, PDCD1LG1, PDCD1LG1MGC142296, PDL1, PD-L1, PD-L1B7 homolog 1, PDL1PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

31-41 kDa, reducing conditions

theoretical molecular weight :

26 kDa

gene symbol :

CD274

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human PD-L1/B7-H1 is immobilized at 0.025 µg/mL (100 µL/well), the concentration of Recombinant Human PD-1 Fc Chimera (Catalog # 1086-PD ) that produces 50% of the optimal binding response is approximately 0.05-0.3 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9NZQ7

applications :

Binding Activity

source :

HEK293-derived Recombinant Human PD-L1/B7-H1 His-tag Protein, CF

USD :

369

Jul-22 :

399 USD

sizes available :

100 ug

more info or order :

R&D Systems product webpage