Recombinant Mouse IL-6/IL-6R alpha Protein Chimera | R&D Systems 9038-SR-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera

catalog :

9038-SR-025

quantity :

25 ug

price :

456 USD

citations: 6

Reference
M xfc ller S, Shmueli M, Feng X, T xfc shaus J, Schumacher N, Clark R, et al. The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Mol Neurodegener. 2023;18:13 pubmed publisher
Lutz M, Ali S, Audiger C, Autenrieth S, Berod L, Bigley V, et al. Guidelines for mouse and human DC generation. Eur J Immunol. 2022;: pubmed publisher
Chou C, Hua K, Chen M, Wu C, Hsu C, Wang J, et al. Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation. MAbs. 2022;14:2029675 pubmed publisher
Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
Innamarato P, Kodumudi K, Asby S, Schachner B, Hall M, Mackay A, et al. Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy. Mol Ther. 2020;28:2252-2270 pubmed publisher
Xu E, Pereira M, Karakasilioti I, Theurich S, Al Maarri M, Rappl G, et al. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nat Commun. 2017;8:14803 pubmed publisher

product information

master code :

9038-SR

SKU :

9038-SR-025

product name :

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera

unit size :

25 ug

description :

The Recombinant Mouse IL-6/IL-6R alpha Protein Chimera from R&D Systems is derived from NS0. The Recombinant Mouse IL-6/IL-6R alpha Protein Chimera has been validated for the following applications: Bioactivity.

target :

IL-6/IL-6R alpha Complex

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

70-87 kDa, reducing conditions

theoretical molecular weight :

60 kDa

gene symbol :

Il6

details of functionality :

Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2-12 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera Bioactivity

accessionNumbers :

P22272 (IL-6 R alpha ) P08505 (IL-6)

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse IL-6/IL-6R alpha Complex protein Mouse IL-6R alpha (Leu20-Glu357) Accession # P22272 GGGSGGGSGGGS Mouse IL-6 (Phe25-Thr211) Accession # P08505 N-terminus C-terminus

source short :

NS0

USD :

456 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.