Recombinant Mouse IL-6/IL-6R alpha Protein Chimera, CF | R&D Systems 9038-SR-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera, CF

catalog :

9038-SR-025/CF

quantity :

25 ug

price :

447 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
M xfc ller S, Shmueli M, Feng X, T xfc shaus J, Schumacher N, Clark R, et al. The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Mol Neurodegener. 2023;18:13 pubmed publisher
Lutz M, Ali S, Audiger C, Autenrieth S, Berod L, Bigley V, et al. Guidelines for mouse and human DC generation. Eur J Immunol. 2022;: pubmed publisher
Innamarato P, Kodumudi K, Asby S, Schachner B, Hall M, Mackay A, et al. Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy. Mol Ther. 2020;28:2252-2270 pubmed publisher
Xu E, Pereira M, Karakasilioti I, Theurich S, Al Maarri M, Rappl G, et al. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nat Commun. 2017;8:14803 pubmed publisher

image

image 1 :

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

9038-SR/CF

SKU :

9038-SR-025/CF

product name :

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera, CF

Description :

The Recombinant Mouse IL-6/IL-6R alpha Protein Chimera, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-6/IL-6R alpha Protein Chimera, CF has been validated for the following applications: Bioactivity.

target :

IL-6/IL-6R alpha Complex

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

70-87 kDa, reducing conditions

theoretical molecular weight :

60 kDa

gene symbol :

Il6

details of functionality :

Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2-12 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P22272 (IL-6 R alpha ) P08505 (IL-6)

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse IL-6/IL-6R alpha Protein Chimera

USD :

447 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage